van Wendel de Joode Berna, Vermeulen Roel, Heederik Dick, van Ginkel Kees, Kromhout Hans
Risk Assessment in the Work Environment, a collaborative centre between TNO Quality of Life and IRAS Utrecht University, Utrecht, the Netherlands.
Contact Dermatitis. 2007 Jul;57(1):14-20. doi: 10.1111/j.1600-0536.2007.01127.x.
We performed an exploratory study to evaluate 2 self-administered questionnaires assessing hand dermatitis and to investigate a possible exposure-response relation between dermal exposure to semi-synthetic metal working fluids (SMWF) and dermatitis. In a cross-sectional survey on dermatitis, a symptom-based questionnaire and a picture-based skin-screening list were applied in 80 SMWF-exposed workers and 67 referents. To evaluate accuracy of the questionnaires, 47 subjects were examined by a dermatologist. Dermal exposure levels to SMWF were assessed on the hands, forearms, and face with an observational method that was validated with a fluorescent-tracer method. The symptom-based questionnaire had a relatively high sensitivity (0.86) but moderate specificity (0.64), the skin-screening list had a low sensitivity (0.36) and a relatively high specificity (0.84). The skin-screening list seemed to represent the more severe cases of dermatitis and showed a significant relation to exposure, for dermatitis on hands, forearms, or face. In epidemiological surveys where workers are not seen by a dermatologist, the skin-screening list seems to be more appropriate to detect cases of dermatitis, as its higher specificity results in less false positives. Alternatively, it would be preferable to apply the symptom-based questionnaire; workers with symptoms should be seen by a dermatologist to identify false positives.
我们进行了一项探索性研究,以评估两份用于评估手部皮炎的自填式问卷,并调查皮肤接触半合成金属加工液(SMWF)与皮炎之间可能存在的暴露-反应关系。在一项关于皮炎的横断面调查中,对80名接触SMWF的工人和67名对照人员应用了基于症状的问卷和基于图片的皮肤筛查清单。为了评估问卷的准确性,皮肤科医生对47名受试者进行了检查。采用荧光示踪法验证的观察方法对手部、前臂和面部的SMWF皮肤暴露水平进行了评估。基于症状的问卷具有相对较高的敏感性(0.86)但特异性中等(0.64),皮肤筛查清单的敏感性较低(0.36)而特异性相对较高(0.84)。皮肤筛查清单似乎代表了更严重的皮炎病例,并且显示出与手部、前臂或面部皮炎的暴露有显著关系。在未由皮肤科医生检查工人的流行病学调查中,皮肤筛查清单似乎更适合检测皮炎病例,因为其较高的特异性导致假阳性较少。或者,应用基于症状的问卷会更好;有症状的工人应由皮肤科医生检查以识别假阳性。