Tamura Atsuhisa, Hebisawa Akira, Iuchi Keiji, Maeda Hajime, Fukai Shimao, Komatsu Hikotaro, Kawahara Masaaki
National Hospital Organization Study Group for Lung Cancer in Japan, and Department of Respiratory Diseases, National Hospital Organization Tokyo National Hospital, Tokyo, Japan.
Respirology. 2008 Jun;13(4):585-9. doi: 10.1111/j.1440-1843.2008.01281.x. Epub 2008 Apr 10.
The aim of this study was to describe the features of lung cancers associated with chronic tuberculous pyothorax.
Clinicopathological data from patients with coexisting lung cancer and chronic latent pyothorax caused by tuberculosis (TB) were analysed, and cancer tissue samples were investigated for the presence of Epstein-Barr virus.
Twelve patients were identified, and all had a history of tuberculous pleuritis or surgical intervention for TB. The interval between the onset of TB and lung cancer was more than 30 years in nine patients and the most frequent symptom was chest pain (six patients). All cancers were in the ipsilateral lung to the pyothorax, and in nine of the 12 patients the cancers were located adjacent to the pyothorax. In situ hybridization analysis for Epstein-Barr virus-encoded small RNA failed to show positive signals in any of the six cancer tissues examined.
Lung cancer associated with chronic pyothorax always developed in the ipsilateral lung to the pyothorax, and there was no evidence for the presence of Epstein-Barr virus in the cancer tissues examined.
本研究旨在描述与慢性结核性脓胸相关的肺癌特征。
分析了同时患有肺癌和由结核病（TB）引起的慢性潜伏性脓胸患者的临床病理数据，并对癌组织样本进行了爱泼斯坦 - 巴尔病毒检测。
共确定了12例患者，所有患者均有结核性胸膜炎病史或因结核病接受过手术治疗。9例患者结核病发病与肺癌发病的间隔时间超过30年，最常见的症状是胸痛（6例患者）。所有癌症均位于脓胸同侧肺，12例患者中有9例癌症位于脓胸附近。对6个癌组织进行的爱泼斯坦 - 巴尔病毒编码小RNA原位杂交分析未显示任何阳性信号。
与慢性脓胸相关的肺癌总是发生在脓胸同侧肺，在所检测的癌组织中没有证据表明存在爱泼斯坦 - 巴尔病毒。
Zotero 插件