Department of Neurology, Columbia University, New York, NY, United States.
Epilepsy Res. 2011 Feb;93(2-3):115-9. doi: 10.1016/j.eplepsyres.2010.11.005. Epub 2010 Dec 21.
Recent studies have provided much needed data on the probability of seizure remission among adults with chronic intractable epilepsy treated medically. Here we provide an extended follow-up to our earlier study in order to provide a more comprehensive picture of long-term prognosis in this patient population during medical treatment. The prevalence cohort was followed for two outcomes-complete seizure remission for ≥ 12 months and subsequent seizure relapse among those attaining a seizure remission. The study outcomes were estimated using Kaplan-Meier analysis. We found that the probability of attaining a ≥ 12 months of complete seizure freedom to be approximately 3-4% per year through 8 years of follow-up. By year 5 since the start of seizure remission, the cumulative probability of seizure relapse was 81%, although only half of the patients with seizure relapse went on to experience their previous seizure frequency.
最近的研究为慢性难治性癫痫成年患者接受药物治疗后癫痫缓解的可能性提供了急需的数据。在这里，我们对早期的研究进行了扩展随访，以便在药物治疗期间为这一患者群体的长期预后提供更全面的情况。患病率队列随访了两个结果——完全无癫痫发作持续 12 个月以上，以及那些达到癫痫缓解的患者随后癫痫发作复发。使用 Kaplan-Meier 分析来估计研究结果。我们发现，通过 8 年的随访，每年达到完全无癫痫发作持续 12 个月的概率约为 3-4%。自癫痫缓解开始后 5 年，癫痫复发的累积概率为 81%，尽管只有一半的癫痫复发患者继续经历之前的癫痫发作频率。
