Workowski Kimberly A, Berman Stuart M, Douglas John M
National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, and Emory University, Atlanta, Georgia, USA.
Ann Intern Med. 2008 Apr 15;148(8):606-13. doi: 10.7326/0003-4819-148-8-200804150-00005.
Prevention and control of gonorrhea is an important public health concern due to the high burden of disease, the recent increase in reported infection rates, and the reproductive and economic consequences of infection. Effective antibiotic treatment is one essential component of an integrated approach to gonorrhea control. Over the past 60 years, however, development of resistance in Neisseria gonorrhoeae to multiple antimicrobial classes challenges this component of gonorrhea control. An integrated, comprehensive prevention strategy should include enhancement of national and international surveillance systems to monitor antimicrobial resistance and new strategies to maximize the benefit and prolong the utility of antimicrobials, including combination regimens, implementation of screening recommendations for individuals at high risk for infection, and the assurance of prompt and effective treatment for infected persons and their sexual partners. Progress in controlling the epidemic and avoiding a resurgence as treatment options wane will require careful attention to all components of a comprehensive prevention strategy.
由于淋病疾病负担沉重、近期报告的感染率上升以及感染对生殖和经济造成的后果，淋病的预防和控制是一个重要的公共卫生问题。有效的抗生素治疗是淋病综合防控方法的一个重要组成部分。然而，在过去60年里，淋病奈瑟菌对多种抗菌药物产生耐药性，这对淋病防控的这一组成部分构成了挑战。综合、全面的预防策略应包括加强国家和国际监测系统以监测抗菌药物耐药性，以及采用新策略以最大限度地提高抗菌药物的效益并延长其效用，包括联合用药方案、对感染高危个体实施筛查建议，以及确保为感染者及其性伴侣提供及时有效的治疗。随着治疗选择减少，要控制疫情并避免疫情复发，就需要密切关注综合预防策略的所有组成部分。
