Liu Jing-Wei, Xu Wen-Qi, Zhu Xiao-Yu, Dai Xiu-Qin, Chen Shao-Chun, Han Yan, Liu Jun, Chen Xiang-Sheng, Yin Yue-Ping
Institute of Dermatology and Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, People's Republic of China.
National Center for Sexually Transmitted Diseases Control, Chinese Center for Disease Control and Prevention, Nanjing, People's Republic of China.
Infect Drug Resist. 2019 Aug 9;12:2471-2476. doi: 10.2147/IDR.S214059. eCollection 2019.
Gentamicin is a promising antimicrobial for the treatment of gonorrhea. The study aimed to evaluate gentamicin minimum inhibitory concentrations (MICs) of isolates in China.
In this study, the agar dilution method was used to determine the MICs of 470 isolates collected in 2016 to four effective antimicrobials (gentamicin, azithromycin, ceftriaxone, and spectinomycin).
Gentamicin MICs ranged from 1 to 8 mg/L. No isolate was resistant to gentamicin. Of seven isolates simultaneously resistant to azithromycin and ceftriaxone, 6 isolates demonstrated MICs of 4 mg/L or less to gentamicin. No cross relationships were found between MICs of gentamicinand susceptibility profiles of azithromycin, ceftriaxone, and spectinomycin.
The in vitro results suggest that gentamicin can be a promising treatment option for gonococcal infections in China. Clinical trials to evaluate the therapeutic efficacy of gentamicin are required.
庆大霉素是一种有前景的用于治疗淋病的抗菌药物。本研究旨在评估中国分离株的庆大霉素最低抑菌浓度（MIC）。
在本研究中，采用琼脂稀释法测定2016年收集的470株分离株对四种有效抗菌药物（庆大霉素、阿奇霉素、头孢曲松和大观霉素）的MIC。
庆大霉素的MIC范围为1至8mg/L。没有分离株对庆大霉素耐药。在七株同时对阿奇霉素和头孢曲松耐药的分离株中，6株对庆大霉素的MIC为4mg/L或更低。庆大霉素的MIC与阿奇霉素、头孢曲松和大观霉素的敏感性谱之间未发现交叉关系。
体外研究结果表明，庆大霉素可能是中国淋病奈瑟菌感染的一种有前景的治疗选择。需要进行临床试验以评估庆大霉素的治疗效果。
