Miller Sven, Krijnse-Locker Jacomine
3-V Biosciences, Institute of Biochemistry, Schafmattstrasse 18, ETH Hoenggerberg, HPME 17, CH8093 Zurich, Switzerland.
Nat Rev Microbiol. 2008 May;6(5):363-74. doi: 10.1038/nrmicro1890.
Viruses are intracellular parasites that use the host cell they infect to produce new infectious progeny. Distinct steps of the virus life cycle occur in association with the cytoskeleton or cytoplasmic membranes, which are often modified during infection. Plus-stranded RNA viruses induce membrane proliferations that support the replication of their genomes. Similarly, cytoplasmic replication of some DNA viruses occurs in association with modified cellular membranes. We describe how viruses modify intracellular membranes, highlight similarities between the structures that are induced by viruses of different families and discuss how these structures could be formed.
病毒是细胞内寄生虫，它们利用所感染的宿主细胞产生新的感染性后代。病毒生命周期的不同阶段与细胞骨架或细胞质膜相关联，这些结构在感染过程中常常会发生改变。正链RNA病毒会诱导膜增殖以支持其基因组的复制。同样，一些DNA病毒的细胞质复制也与修饰后的细胞膜相关。我们描述了病毒如何修饰细胞内膜，强调了不同病毒家族诱导产生的结构之间的相似性，并讨论了这些结构是如何形成的。
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