N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺和N-乙酰葡糖胺基-(β1→4)-N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺的免疫调节特性研究
Study of immunomodulatory properties of N-acetylmuramyl-L-alanyl-D-isoglutamine and N-acetylglucosaminyl-(beta 1----4)-N-acetylmuramyl-L-alanyl-D-isoglutamine.
作者信息
Dozmorov I M, Kuzin I I, Lutsan N I, Lutsenko G V, Prokhorova A L, Sapozhnikov A M, Andronova T M, Ivanov V T
机构信息
Department of Immunology, Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.
出版信息
Biomed Sci. 1991;2(6):651-8.
The immunomodulatory activities of two synthetic muramylpeptides (MP), a muramyl dipeptide and a glucosaminyl-muramyl dipeptide, have been compared and have been found to exhibit many common features in their effects. In addition, the differential effects of low and high concentrations of MP on the primary humoral immune response in vitro were examined in detail. At high concentrations MP augmented the frequency of induced T-suppressor cells, while at low concentrations the primary immune response was stimulated by enhancement of the antigen-presenting function of accessory cells and by increasing the frequency of induced T-helper cells.
两种合成的胞壁酰肽（MP），即胞壁酰二肽和葡糖胺酰 - 胞壁酰二肽的免疫调节活性已被比较，并且发现在其作用中表现出许多共同特征。此外，还详细研究了低浓度和高浓度MP对体外初次体液免疫反应的不同影响。高浓度时，MP增加了诱导性T抑制细胞的频率，而在低浓度时，通过增强辅助细胞的抗原呈递功能和增加诱导性T辅助细胞的频率来刺激初次免疫反应。
Zotero 插件