合成的胞壁酰二肽（MDP）N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺的免疫佐剂作用。
Immunoadjuvant effects of the synthetic muramyl-dipeptide (MDP) N-acetylmuramyl-L-alanyl-D-isoglutamine.
作者信息
Heymer B, Finger H, Wirsing C H
出版信息
Z Immunitatsforsch Immunobiol. 1978 Oct;155(1):87-92.
PMID:706536
Abstract
The adjuvant activity of the synthetic muramyl-dipeptide (MDP) N-acetyl-muramyl-L-alanyl-D-isoglutamine upon immunization of mice with BSA or SRBC was studied. MDP was found to significantly increase BSA-antibody formation and to favour the induction of anaphylactic reactions to BSA. In contrast, under the conditions employed, MDP only weakly stimulated the immune response to SRBC.
摘要
研究了合成的胞壁酰二肽（MDP）N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺在小鼠用牛血清白蛋白（BSA）或绵羊红细胞（SRBC）免疫时的佐剂活性。发现MDP能显著增加BSA抗体的形成，并有利于诱导对BSA的过敏反应。相比之下，在所采用的条件下，MDP对SRBC免疫反应的刺激作用较弱。
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