Yanai Hidekatsu, Tomono Yoshiharu, Ito Kumie, Furutani Nobuyuki, Yoshida Hiroshi, Tada Norio
Department of Internal Medicine, The Jikei University School of Medicine, Chiba, Japan.
Nutr J. 2008 Apr 17;7:10. doi: 10.1186/1475-2891-7-10.
High blood pressure is an important constituent of the metabolic syndrome. However, the underlying mechanisms for development of hypertension in the metabolic syndrome are very complicated and remain still obscure. Visceral/central obesity, insulin resistance, sympathetic overactivity, oxidative stress, endothelial dysfunction, activated renin-angiotensin system, increased inflammatory mediators, and obstructive sleep apnea have been suggested to be possible factors to develop hypertension in the metabolic syndrome. Here, we will discuss how these factors influence on development of hypertension in the metabolic syndrome.
高血压是代谢综合征的重要组成部分。然而，代谢综合征中高血压发生的潜在机制非常复杂，仍不清楚。内脏/中心性肥胖、胰岛素抵抗、交感神经过度活跃、氧化应激、内皮功能障碍、肾素-血管紧张素系统激活、炎症介质增加以及阻塞性睡眠呼吸暂停被认为是代谢综合征中发生高血压的可能因素。在此，我们将讨论这些因素如何影响代谢综合征中高血压的发生。
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