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早发冠心病患者食用发酵和未发酵乳制品与高血压之间的关系:伊朗早发冠心病研究

The relationship between fermented and nonfermented dairy products consumption and hypertension among premature coronary artery disease patients: Iran premature coronary artery disease study.

作者信息

Ansari Shakila, Mohammadifard Noushin, Hajihashemi Parisa, Haghighatdoost Fahimeh, Zarepur Ehsan, Mahmoudi Shirin, Nouri Fatemeh, Nouhi Fereydoon, Kazemi Tooba, Salehi Nahid, Solati Kamal, Ghaffari Samad, Gholipour Mahboobeh, Dehghani Mostafa, Cheraghi Mostafa, Heybar Habib, Alikhasi Hassan, Sarrafzadegan Nizal

机构信息

Department of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science Isfahan University of Medical Sciences Isfahan Iran.

Interventional Cardiology Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran.

出版信息

Food Sci Nutr. 2024 Feb 8;12(5):3322-3335. doi: 10.1002/fsn3.3998. eCollection 2024 May.

Abstract

Dairy products may affect hypertension (HTN) risk. The aim of this study was to examine the association between fermented and nonfermented dairy foods and HTN in a sample of premature coronary artery disease (PCAD) subjects. This cross-sectional study was performed on 1854 PCAD patients. A 110-item food frequency questionnaire was used to assess dietary intakes. HTN was considered if systolic blood pressure was 140 mmHg and higher and/or diastolic blood pressure was 90 mmHg and higher. The odds ratio of HTN across the quartiles of different types of dairy products was evaluated by binary logistic regression. The mean (SD) of dairy products consumption was 339.8 (223.5) g/day, of which 285.4 g/day was fermented dairy products. In the crude model, participants in the fourth quartile of fermented dairy products had lesser risk of HTN compared to the bottom quartile (OR = 0.70, 95% CI: 0.52, 0.96; for trend = .058). However, after considering the possible confounders, the significance disappeared. Subjects in the top quartile of high-fat fermented dairy products had 34% lower risk for HTN compared to the bottom quartile (95% CI: 0.49, 0.88; for trend < .001). Adjustment for potential risk factors weakened the association but remained significant (OR = 0.73, 95% CI: 0.53, 1.01; for trend = .001). Nonsignificant relation was detected between low-fat fermented, low-fat nonfermented, and high-fat nonfermented dairy products and HTN. Moderate consumption of high-fat fermented dairy products, in a population with low consumption of dairy foods, might relate to reduced likelihood of HTN.

摘要

乳制品可能会影响高血压(HTN)风险。本研究的目的是在一组早发性冠状动脉疾病(PCAD)受试者样本中,研究发酵乳制品和未发酵乳制品与高血压之间的关联。这项横断面研究对1854名PCAD患者进行。采用一份包含110个条目的食物频率问卷来评估饮食摄入量。如果收缩压为140 mmHg及以上和/或舒张压为90 mmHg及以上,则被认为患有高血压。通过二元逻辑回归评估不同类型乳制品四分位数水平上高血压的比值比。乳制品的平均(标准差)摄入量为339.8(223.5)克/天,其中发酵乳制品为285.4克/天。在粗模型中,与最低四分位数相比,处于发酵乳制品第四四分位数的参与者患高血压的风险较低(比值比=0.70,95%置信区间:0.52,0.96;趋势P值=0.058)。然而,在考虑了可能的混杂因素后,这种显著性消失了。与最低四分位数相比,处于高脂肪发酵乳制品最高四分位数的受试者患高血压的风险降低了34%(95%置信区间:0.49,0.88;趋势P值<0.001)。对潜在风险因素进行调整后,这种关联有所减弱,但仍然显著(比值比=0.73,95%置信区间:0.53,1.01;趋势P值=0.001)。未检测到低脂发酵乳制品、低脂未发酵乳制品和高脂未发酵乳制品与高血压之间存在显著关联。在乳制品摄入量较低的人群中,适度食用高脂肪发酵乳制品可能与降低患高血压的可能性有关。

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