von Ah Ueli, Wirz Dieter, Daniels A U
Laboratory for Orthopaedic Biomechanics, Clinical Morphology & Biomedical Engineering, University of Basel Faculty of Medicine, Basel, Switzerland.
J Clin Microbiol. 2008 Jun;46(6):2083-7. doi: 10.1128/JCM.00611-08. Epub 2008 Apr 16.
In this study, the use of isothermal microcalorimetry (IMC) for differentiation between methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) and MIC determination was evaluated. It was possible to differentiate between MRSA and MSSA within 4 h, whereas the standard method required 24 h. The MICs of cefoxitin were successfully determined for MRSA and MSSA by using IMC.
在本研究中,评估了使用等温微量热法(IMC)区分耐甲氧西林金黄色葡萄球菌(MRSA)和甲氧西林敏感金黄色葡萄球菌(MSSA)以及测定最低抑菌浓度(MIC)的情况。4小时内即可区分MRSA和MSSA,而标准方法需要24小时。通过IMC成功测定了MRSA和MSSA对头孢西丁的MIC。