Méndez-Ramírez Francisco, Barbosa-Sabanero Gloria, Romero-Gutiérrez Gustavo, Malacara Juan Manuel
Instituto de Investigaciones Médicas, Universidad de Guanajuato, Guanajuato, México.
Clin Endocrinol (Oxf). 2009 Jan;70(1):41-6. doi: 10.1111/j.1365-2265.2008.03278.x. Epub 2008 Apr 16.
Small-for-gestational newborn babies may have long-term metabolic consequences. Among the main hormones possibly involved in foetal growth regulation are the IGFs, IGFBPs and the recently described ghrelin.
To examine the levels of desacyl-ghrelin, IGF-1, IGFBP-1 and IGFBP-3 in children Small-for-gestational age (SGA) and children adequate-for-gestational age (AGA).
This was a cross-sectional and comparative study.
We included 40 children SGA and 40 children AGA.
Blood sample was taken a week after birth and measuring hormonal levels were done by ELISA.
SGA babies had lower IGF-1, IGFBP-3 and leptin levels, but higher ghrelin and IGFBP-1 levels. Birth weight was associated independently with ghrelin and IGFBP-1 (negatively) and IGFBP-3 (positively). Ghrelin circulating levels were associated negative and independently with IGFBP-3 and triglycerides in the mother.
We interpreted these findings to indicate that diminished body weight in newborns induce different adaptive signals, some of them mediated by IGF-1/IGFBP-3, ghrelin or by IGFBP-1. This regulation is congruent with the proposed role of ghrelin to adaptation to under-nutrition favouring lipid accumulation. CONCyTEG grant number 05-16-K117-028.
小于胎龄新生儿可能会有长期的代谢后果。可能参与胎儿生长调节的主要激素包括胰岛素样生长因子（IGFs）、胰岛素样生长因子结合蛋白（IGFBPs）以及最近发现的胃饥饿素。
检测小于胎龄（SGA）儿童和适于胎龄（AGA）儿童中去酰基胃饥饿素、IGF-1、IGFBP-1和IGFBP-3的水平。
这是一项横断面比较研究。
我们纳入了40名SGA儿童和40名AGA儿童。
出生一周后采集血样，采用酶联免疫吸附测定法（ELISA）检测激素水平。
SGA婴儿的IGF-1、IGFBP-3和瘦素水平较低，但胃饥饿素和IGFBP-1水平较高。出生体重与胃饥饿素和IGFBP-1呈负相关，与IGFBP-3呈正相关。循环中的胃饥饿素水平与母亲的IGFBP-3和甘油三酯呈负相关且独立相关。
我们认为这些发现表明新生儿体重减轻会引发不同的适应性信号，其中一些由IGF-1/IGFBP-3、胃饥饿素或IGFBP-1介导。这种调节与胃饥饿素在适应营养不良以促进脂质积累方面的作用一致。CONCyTEG资助编号为：05-16-K117-028。
