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一项关于单次高胆固醇饮食对健康及患病人类志愿者所引起的短期脂蛋白变化的研究。

A study of short term lipoprotein changes induced by single high cholesterol diet in healthy and diseases human volunteers.

作者信息

Arora R C, Agarwal N, Singh D K

机构信息

Dept. of Medicine, MLB Medical College, Jhansi, India.

出版信息

Mater Med Pol. 1991 Oct-Dec;23(4):299-301.

PMID:1842237
Abstract

Changes in lipid lipoprotein profile were observed in the first and third hours after feeding 750 mg of egg cholesterol in 13 healthy male subjects (Group A), 6 patients of coronary artery disease (Group B), 10 diabetic patients (Group C), and 10 hypertensive patients (Group D), all belonging to the age group of 35-60 years. 61.53% of healthy male subjects showed a fall in the total serum cholesterol (STC) in the first hour after feeding, while in the rest there was a rise. On the other hand, 66.67% of coronary artery disease patients, 50% of diabetics and 50% hypertensives showed a rise in the first hour while the rest showed either a fall or no change in STC. All groups showed a fall in LDL at the first hour. In the third hour the STC and LDL level increased in group A, C and D, whereas in group B STC showed a fall and LDL showed a rise. All these changes were, however, statistically insignificant. The changes in HDL values were also statistically insignificant except in group D where they showed a progressive rise increase in the first and third hours.

摘要

在13名健康男性受试者(A组)、6名冠心病患者(B组)、10名糖尿病患者(C组)和10名高血压患者(D组)中观察了摄入750毫克鸡蛋胆固醇后第一小时和第三小时血脂脂蛋白谱的变化,所有受试者年龄均在35 - 60岁之间。61.53%的健康男性受试者在进食后第一小时血清总胆固醇(STC)下降,而其余受试者则上升。另一方面,66.67%的冠心病患者、50%的糖尿病患者和50%的高血压患者在第一小时STC上升,而其余患者STC要么下降要么无变化。所有组在第一小时LDL均下降。在第三小时,A组、C组和D组的STC和LDL水平升高,而B组STC下降,LDL上升。然而,所有这些变化在统计学上均无显著意义。HDL值的变化在统计学上也无显著意义,除了D组,该组在第一小时和第三小时呈逐渐上升趋势。

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