Mura Anna, Pintus Francesca, Fais Antonella, Porcu Simona, Corda Marcella, Spanò Delia, Medda Rosaria, Floris Giovanni
Department of Applied Sciences in Biosystems, University of Cagliari, I-09042 Monserrato, CA, Italy.
Arch Biochem Biophys. 2008 Jul 1;475(1):18-24. doi: 10.1016/j.abb.2008.03.034. Epub 2008 Apr 7.
Tyramine, an important plant intermediate, was found to be a substrate for two proteins, a copper amine oxidase and a peroxidase from Euphorbia characias latex. The oxidation of tyramine took place by two different mechanisms: oxidative deamination to p-hydroxyphenylacetaldehyde by the amine oxidase and formation of di-tyramine by the peroxidase. The di-tyramine was further oxidized at the two amino groups by the amino oxidase, whereas p-hydroxyphenylacetaldehyde was transformed to di-p-hydroxyphenylacetaldehyde by the peroxidase. Data obtained in this study indicate a new interesting scenario in the metabolism of tyramine.
酪胺是一种重要的植物中间体，被发现是两种蛋白质的底物，即来自大戟乳胶的铜胺氧化酶和过氧化物酶。酪胺的氧化通过两种不同的机制进行：胺氧化酶将其氧化脱氨生成对羟基苯乙醛，过氧化物酶则生成二酪胺。二酪胺被胺氧化酶进一步氧化两个氨基，而对羟基苯乙醛则被过氧化物酶转化为二对羟基苯乙醛。本研究获得的数据表明酪胺代谢中出现了一个新的有趣情况。
