Xerri Christian
Neurobiologie Intégrative et Adaptative, UMR 6149, Université de Provence/Centre National de la Recherche Scientifique, 3 Place Victor Hugo, Marseille Cedex 03, France.
Behav Brain Res. 2008 Sep 1;192(1):26-41. doi: 10.1016/j.bbr.2008.02.038. Epub 2008 Mar 6.
Over the past 30 years, extensive research has been conducted in the field of cortical plasticity, under the impetus of seminal studies showing that the mature brain retains a capacity to reorganize the morphological and functional architecture of its neural circuits in order to adapt to environmental changes and mediate functional recovery following injury. Much effort has been focused on determining how idiosyncratic experience translates into molecular, structural and physiological changes in the sensory and motor representations embedded within cortical networks. The wealth of data generated by a broad spectrum of experimental manipulations has allowed unprecedented progress in our understanding of the physiological processes and neuroplasticity mechanisms underlying cortical representational remodeling. The objective of the present review is to put various facets of cortical map plasticity into perspective so as to examine possible links between changes occurring at multiple scales of the neural organization of the mature brain. The main focus is on neural substrates that mediate the instructive influence of experience and behavioral context on cortical reorganization, and perceptual correlates of representational remodeling.
在过去30年里，在一些开创性研究的推动下，人们对皮质可塑性领域进行了广泛研究。这些研究表明，成熟大脑保留了重新组织其神经回路的形态和功能结构的能力，以适应环境变化并介导损伤后的功能恢复。大量努力集中在确定独特的经验如何转化为皮质网络中嵌入的感觉和运动表征的分子、结构和生理变化。广泛的实验操作产生的大量数据使我们在理解皮质表征重塑背后的生理过程和神经可塑性机制方面取得了前所未有的进展。本综述的目的是全面审视皮质图谱可塑性的各个方面，以便研究成熟大脑神经组织多个尺度上发生的变化之间的可能联系。主要重点是介导经验和行为背景对皮质重组的指导性影响的神经基质，以及表征重塑的感知相关因素。
