Araiz Caroline, Château Marie-Thérèse, Galas Simon
CRBM-CNRS, 1919 route de Mende, F34293 Montpellier cedex 5, France.
Exp Gerontol. 2008 Jun;43(6):505-19. doi: 10.1016/j.exger.2008.03.001. Epub 2008 Mar 18.
Caenorhabditis elegans life span, stress resistance and metabolism are regulated by the Insulin/IGF-1/DAF-2/DAF-16 pathway. DAF-16, a member of FOXO/Forkhead transcription factor family, can be targeted by 14-3-3 proteins to promote stress resistance. We have identified a 14-3-3 C. elegans homolog which promotes life span by both DAF-2-dependent and -independent mechanisms and by an unexpected DAF-16-independent mechanism. Our results demonstrate that C. elegans 14-3-3 proteins modulate stress-responsive genes throughout adulthood. In conclusion, 14-3-3 can be considered as an acute stress-responsive regulator as well as a sustained modulator of the Insulin/IGF-1/DAF-2/DAF-16 regulatory pathway in promoting life expectancy of growing old worms.
秀丽隐杆线虫的寿命、抗逆性和新陈代谢受胰岛素/胰岛素样生长因子-1/DAF-2/DAF-16信号通路调控。DAF-16是FOXO/叉头转录因子家族的成员之一，可被14-3-3蛋白靶向，以增强抗逆性。我们鉴定出一种秀丽隐杆线虫14-3-3同源物，它通过依赖DAF-2和不依赖DAF-2的机制以及一种意想不到的不依赖DAF-16的机制来延长寿命。我们的结果表明，秀丽隐杆线虫14-3-3蛋白在整个成年期调节应激反应基因。总之，14-3-3可被视为一种急性应激反应调节因子，也是胰岛素/胰岛素样生长因子-1/DAF-2/DAF-16调节通路的持续调节因子，可促进衰老线虫的预期寿命。
