Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Antioxid Redox Signal. 2011 Feb 15;14(4):623-34. doi: 10.1089/ars.2010.3490. Epub 2010 Nov 30.
The Caenorhabditis elegans Forkhead box O transcription factor (FOXO) homolog DAF-16 functions as a central mediator of multiple biological processes such as longevity, development, fat storage, stress resistance, and reproduction. In C. elegans, similar to other systems, DAF-16 functions as the downstream target of a conserved, well-characterized insulin/insulin-like growth factor (IGF)-1 signaling pathway. This cascade is comprised of an insulin/IGF-1 receptor, which signals through a conserved PI 3-kinase/AKT pathway that ultimately downregulates DAF-16/FOXO activity. Importantly, studies have shown that multiple pathways intersect with the insulin/IGF-1 signaling pathway and impinge on DAF-16 for their regulation. Therefore, in C. elegans, the single FOXO family member, DAF-16, integrates signals from several pathways and then regulates its many downstream target genes.
秀丽隐杆线虫的叉头框 O 转录因子（FOXO）同源物 DAF-16 作为多种生物学过程的中央介质起作用，例如寿命、发育、脂肪储存、应激抗性和繁殖。在秀丽隐杆线虫中，与其他系统相似，DAF-16 作为保守的、特征明确的胰岛素/胰岛素样生长因子 (IGF)-1 信号通路的下游靶标发挥作用。该级联反应由胰岛素/IGF-1 受体组成，该受体通过保守的 PI 3-激酶/AKT 途径发出信号，最终下调 DAF-16/FOXO 活性。重要的是，研究表明，多条途径与胰岛素/IGF-1 信号通路相交，并通过其对 DAF-16 的调节来影响 DAF-16。因此，在秀丽隐杆线虫中，单一的 FOXO 家族成员 DAF-16 整合了来自多个途径的信号，然后调节其许多下游靶基因。
