14-3-3 蛋白处于癌症、衰老和与年龄相关的神经退行性疾病的十字路口。
14-3-3 Proteins Are on the Crossroads of Cancer, Aging, and Age-Related Neurodegenerative Disease.
机构信息
Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, Sichuan, China.
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, Sichuan, China.
出版信息
Int J Mol Sci. 2019 Jul 18;20(14):3518. doi: 10.3390/ijms20143518.
14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. These proteins participate in a variety of intracellular processes by recognizing specific phosphorylation motifs and interacting with hundreds of target proteins. Also, 14-3-3 proteins act as molecular chaperones, preventing the aggregation of unfolded proteins under conditions of cellular stress. Furthermore, 14-3-3 proteins have been shown to have similar expression patterns in tumors, aging, and neurodegenerative diseases. Therefore, we put forward the idea that the adaptor activity and chaperone-like activity of 14-3-3 proteins might play a substantial role in the above-mentioned conditions. Interestingly, 14-3-3 proteins are considered to be standing at the crossroads of cancer, aging, and age-related neurodegenerative diseases. There are great possibilities to improve the above-mentioned diseases and conditions through intervention in the activity of the 14-3-3 protein family.
14-3-3 蛋白是一组保守的调节衔接分子家族，存在于所有真核细胞中。这些蛋白通过识别特定的磷酸化模体并与数百种靶蛋白相互作用，参与多种细胞内过程。此外，14-3-3 蛋白还可以作为分子伴侣发挥作用，在细胞应激条件下防止未折叠蛋白的聚集。此外，已经证明 14-3-3 蛋白在肿瘤、衰老和神经退行性疾病中有相似的表达模式。因此，我们提出这样的观点，即 14-3-3 蛋白的衔接活性和分子伴侣样活性可能在上述条件中发挥重要作用。有趣的是，14-3-3 蛋白被认为处于癌症、衰老和与年龄相关的神经退行性疾病的十字路口。通过干预 14-3-3 蛋白家族的活性，有很大的可能性改善上述疾病和状况。
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