Boyd Scott D
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305-2297, USA.
Lab Invest. 2008 Jun;88(6):569-78. doi: 10.1038/labinvest.2008.32. Epub 2008 Apr 21.
MicroRNAs are a class of recently discovered small RNA molecules that regulate other genes in the human genome. Studies in human cells and model organisms have begun to reveal the mechanisms of microRNA activity, and the wide range of normal physiological functions they influence. Their alteration in pathologic states from cancer to cardiovascular disease is also increasingly clear. A review of current evidence for the role of these molecules in human health and disease will be helpful to pathologists and medical researchers as the fascinating story of these small regulators continues to unfold.
微小RNA是一类最近发现的小RNA分子，它们调控人类基因组中的其他基因。对人类细胞和模式生物的研究已开始揭示微小RNA的活性机制，以及它们所影响的广泛正常生理功能。它们在从癌症到心血管疾病等病理状态下的改变也日益明显。随着这些小调节因子的迷人故事不断展开，综述这些分子在人类健康和疾病中作用的当前证据，将对病理学家和医学研究人员有所帮助。
