Zeng Yan
Department of Pharmacology, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Mol Pharmacol. 2009 Feb;75(2):259-64. doi: 10.1124/mol.108.052118. Epub 2008 Nov 12.
The mammalian nervous system exerts essential control on many physiological processes in the organism and is itself controlled extensively by a variety of genetic regulatory mechanisms. MicroRNAs, a class of small, noncoding RNAs, are critical contributors to the regulation of gene expression in the nervous system. Emerging evidence indicates that microRNAs regulate both the development and function of the nervous system. Deficiency in microRNA function has also been implicated in a number of neurological disorders. Understanding the roles of microRNAs will provide new insights into the complexity and operation of the nervous system.
哺乳动物的神经系统对机体的许多生理过程发挥着至关重要的控制作用，其自身也受到多种遗传调控机制的广泛控制。微小RNA是一类小的非编码RNA，是神经系统基因表达调控的关键贡献者。新出现的证据表明，微小RNA调节神经系统的发育和功能。微小RNA功能缺陷也与多种神经疾病有关。了解微小RNA的作用将为神经系统的复杂性和运作提供新的见解。
