Benavides J, Dubois A, Scatton B
Synthélabo Recherche, Bagneux Cédex, France.
Curr Protoc Neurosci. 2001 May;Chapter 7:Unit7.16. doi: 10.1002/0471142301.ns0716s09.
The concentration of peripheral type benzodiazepine binding sites (PTBS) in the brain parenchyma is greatly increased following brain lesions, reflecting the glial reaction and/or presence of hematogenous cells. Thus, PTBS density is a sensitive and reliable marker of brain injury in a large number of experimental models (ischemia, trauma, excitotoxic lesions, brain tumors) and equivalent human neuropathological conditions. PTBS density can be measured using specific radioligands and a conventional binding technique, or by quantitative autoradiography in tissue sections.
脑实质中周围型苯二氮䓬结合位点（PTBS）的浓度在脑损伤后会大幅增加，这反映了胶质反应和/或血源性细胞的存在。因此，在大量实验模型（缺血、创伤、兴奋性毒性损伤、脑肿瘤）以及相应的人类神经病理学状况中，PTBS密度是脑损伤的一个敏感且可靠的标志物。PTBS密度可使用特定放射性配体和传统结合技术进行测量，也可通过组织切片的定量放射自显影术来测定。
