Benavides J, Cornu P, Dennis T, Dubois A, Hauw J J, MacKenzie E T, Sazdovitch V, Scatton B
Laboratoires d'Etudes et de Recherches Synthélabo, Biology Department, Bagneux, France.
Ann Neurol. 1988 Dec;24(6):708-12. doi: 10.1002/ana.410240603.
The topography and magnitude of increase in peripheral type benzodiazepine binding sites (omega 3 sites) was investigated autoradiographically in the brains of patients with ischemic cerebrovascular disease, with multiple sclerosis, and with malignant glioma. 3H-PK 11195, a selective omega 3 site ligand, was employed. A manyfold increase in omega 3 site density was observed in all these disease states; this increase reflects macrophage invasion or glial proliferation or both as demonstrated by neuropathological studies carried out in parallel. There was an excellent spatial correlation between increased omega 3 site densities and extent of the lesion histologically. Specifically, an elevated density of omega 3 sites was observed in the plaques of demyelination in multiple sclerosis patients, in the periphery of infarcted zones in stroke patients, and throughout tumor in patients with grade IV astrocytomas. As our approach is applicable to both tomographic (in vivo) and autoradiographic investigations, imaging of omega 3 sites may be considered for the detection and monitoring of the natural evolution of many disorders of the human central nervous system.
采用放射自显影法，研究了缺血性脑血管疾病、多发性硬化症和恶性胶质瘤患者大脑中周边型苯二氮䓬结合位点（ω3位点）增加的部位及程度。使用了选择性ω3位点配体3H-PK 11195。在所有这些疾病状态下均观察到ω3位点密度增加了许多倍；如同时进行的神经病理学研究所表明的，这种增加反映了巨噬细胞浸润或胶质细胞增殖或两者皆有。ω3位点密度增加与组织学上病变范围之间存在极好的空间相关性。具体而言，在多发性硬化症患者的脱髓鞘斑块中、中风患者梗死区周边以及IV级星形细胞瘤患者的整个肿瘤中均观察到ω3位点密度升高。由于我们的方法适用于断层扫描（体内）和放射自显影研究，因此对于许多人类中枢神经系统疾病的检测和自然病程监测，可考虑对ω3位点进行成像。
