Goodman Marc T, Shvetsov Yurii B, McDuffie Katharine, Wilkens Lynne R, Zhu Xuemei, Ning Lily, Killeen Jeffrey, Kamemoto Lori, Hernandez Brenda Y
Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA.
J Infect Dis. 2008 Apr 1;197(7):957-66. doi: 10.1086/529207.
The majority of anal cancer is associated with human papillomavirus (HPV) infection, yet little is known about women's risk of acquisition of anal HPV infection.
Risk factors for the acquisition of anal HPV infection were examined in a longitudinal cohort study of 431 women, via repeated measurement of HPV DNA.
Seventy percent of women were positive for anal HPV infection at one or more clinic visits from baseline through a follow-up period that averaged 1.3 years. The incidence of a high-risk (HR) infection was 19.5 (95% confidence interval [CI], 16.0-23.6) per 1000 woman-months. The most common incident HR HPV types were HPV-53, -52 and -16. The presence of an HR anal HPV infection at baseline increased the risk of an incident anal infection by 65%. Baseline HR cervical HPV infection also predicted the acquisition of an HR anal HPV infection (odds ratio, 1.81 [95% CI, 1.09-3.02]). Nonviral risk factors for acquisition of HR HPV infection included younger age, lower socioeconomic status, greater lifetime number of sexual partners, past use of hormones, and condom use.
The results of this study suggest that women's risk of anal HPV infection is as common as their risk of cervical HPV infection.
大多数肛管癌与人乳头瘤病毒（HPV）感染相关，但对于女性获得肛管HPV感染的风险知之甚少。
在一项对431名女性的纵向队列研究中，通过重复检测HPV DNA来研究获得肛管HPV感染的危险因素。
从基线到平均随访1.3年的期间内，70%的女性在一次或多次门诊就诊时肛管HPV感染呈阳性。高危（HR）感染的发生率为每1000女性-月19.5例（95%置信区间[CI]，16.0 - 23.6）。最常见的新发HR HPV类型为HPV - 53、- 52和- 16。基线时存在HR肛管HPV感染会使新发肛管感染的风险增加65%。基线HR宫颈HPV感染也可预测获得HR肛管HPV感染（比值比，1.81 [95% CI，1.09 - 3.02]）。获得HR HPV感染的非病毒危险因素包括年龄较小、社会经济地位较低、性伴侣终生数量较多、既往使用激素以及使用避孕套。
本研究结果表明，女性肛管HPV感染的风险与宫颈HPV感染的风险一样常见。
