Kusters Johannes Ma, Heijne Janneke Cm, van Benthem Birgit Hb, King Audrey J, Schim van der Loeff Maarten F
Institute for Infection and Immunity, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands
Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Sex Transm Infect. 2022 Jul 16;99(4):239-47. doi: 10.1136/sextrans-2022-055484.
This study aimed to investigate type-specific concurrent anogenital human papillomavirus (HPV) detection and examine associations with concurrent detection.
Data from a Dutch repeated cross-sectional study among young sexual health clinic visitors (Papillomavirus Surveillance among STI clinic Youngsters in the Netherlands) between 2009 and 2019 were used. Cohen's kappa was used to assess the degree of type-specific concordance of HPV detection between anal and genital sites for 25 HPV genotypes for women and men who have sex with men (MSM) separately. Associations with type-specific concurrent HPV were identified. Receptive anal intercourse (RAI) was forced into the model to investigate its influence.
Among women (n=1492), type-specific concurrent anogenital detection was common; kappa was above 0.4 for 20 genotypes. Among MSM (n=614), kappa was <0.4 for all genotypes. The only significant association with type-specific concurrent anogenital detection among women was genital chlamydia (adjusted OR 1.5, 95% CI 1.1 to 2.2). RAI was not associated.
Type-specific concurrent anogenital HPV detection was common among young women, and uncommon among MSM. For women, concurrent HPV detection was associated with genital chlamydia. Our results are suggestive of autoinoculation of HPV among women.
本研究旨在调查特定类型的肛门生殖器人乳头瘤病毒（HPV）同时检测情况，并检验其与同时检测的相关性。
使用了2009年至2019年间荷兰一项针对年轻性健康门诊就诊者的重复横断面研究（荷兰性传播感染门诊青少年中的乳头瘤病毒监测）的数据。分别对女性和男男性行为者（MSM）的25种HPV基因型，采用科恩kappa系数评估肛门和生殖器部位HPV检测的特定类型一致性程度。确定与特定类型同时感染HPV的相关性。将接受性肛交（RAI）纳入模型以研究其影响。
在女性（n = 1492）中，特定类型的肛门生殖器同时检测很常见；20种基因型的kappa系数高于0.4。在男男性行为者（n = 614）中，所有基因型的kappa系数均<0.4。女性中与特定类型的肛门生殖器同时检测唯一显著相关的是生殖器衣原体感染（校正比值比1.5，95%置信区间1.1至2.2）。接受性肛交与之无关。
特定类型的肛门生殖器HPV同时检测在年轻女性中很常见，在男男性行为者中不常见。对于女性，同时感染HPV与生殖器衣原体感染有关。我们的结果提示女性中存在HPV的自体接种。
