Džundová Monika Nipčová, Sehnal Borek, Zikán Michal, Kocián Roman, Dubová Olga, Hubka Petr, Dostálek Lukáš, Kabele Pavel, Brtnický Tomáš, Slama Jiri
Department of Gynecology and Obstetrics, Bulovka University Hospital, 1st Faculty of Medicine, Charles University, 18081 Prague, Czech Republic.
Department of Gynecology, Obstetrics and Neonatology, General University Hospital, 1st Faculty of Medicine, Charles University, 12808 Prague, Czech Republic.
Biomedicines. 2023 Nov 29;11(12):3183. doi: 10.3390/biomedicines11123183.
The carcinogenicity of HPV infection in the anogenital and oropharyngeal regions is broadly accepted. The aim of the study was to define risk factors for anal and oral HPV infections in high-risk patients with biopsy-proven severe cervical lesions (CIN2+). Altogether immunocompetent 473 females with CIN2+ were categorized into the study group and another 245 women into the control group. The strongest risk factor for anal HPV infection was the presence of cervical HPV infection ( < 0.001). Furthermore, ten or more lifetime sexual partners ( = 0.013), a sexual non-coital contact with the anal area ( < 0.001), and actively practicing anal-penetrative intercourse ( < 0.001) were significantly associated with anal HPV. A history of genital warts in the woman ( = 0.010) and the presence of genital warts in the male partner ( = 0.029) were found statistically significant for the risk of oral HPV infection. Our data suggest that the presence of HPV infection, especially high-risk genotypes, in one anatomical site poses the greatest risk for HPV infection in another anatomical site. The cervix is the main reservoir of infection, but the risk factors for anal and oral HPV infections are dissimilar according to different anatomical distances and more complex routes of transmission.
人乳头瘤病毒（HPV）感染在肛门生殖器和口咽部位的致癌性已被广泛认可。本研究的目的是确定经活检证实患有严重宫颈病变（CIN2+）的高危患者发生肛门和口腔HPV感染的风险因素。总共473名免疫功能正常的CIN2+女性被纳入研究组，另外245名女性被纳入对照组。肛门HPV感染的最强风险因素是宫颈HPV感染的存在（P<0.001）。此外，终身有10个或更多性伴侣（P = 0.013）、与肛门区域有非性交性接触（P<0.001）以及积极进行肛门插入式性交（P<0.001）与肛门HPV感染显著相关。女性有生殖器疣病史（P = 0.010）以及男性伴侣有生殖器疣（P = 0.029）在口腔HPV感染风险方面具有统计学意义。我们的数据表明，一个解剖部位存在HPV感染，尤其是高危基因型，会给另一个解剖部位带来最大的HPV感染风险。子宫颈是主要的感染源，但根据不同的解剖距离和更复杂的传播途径，肛门和口腔HPV感染的风险因素有所不同。
