Cranston Josephine M, Crockett Alan J, Moss John R, Pegram Robert W, Stocks Nigel P
School of Population Health and Clinical Practice, University of Adelaide, Adelaide, SA, Australia.
Med J Aust. 2008 Apr 21;188(S8):S50-2. doi: 10.5694/j.1326-5377.2008.tb01744.x.
To review the literature for any promising strategies for the primary care management of mild-to-moderate asthma and chronic obstructive pulmonary disease (COPD) in adults.
Using "MeSH" terms for COPD, asthma and primary health care, we conducted an extensive literature search for relevant meta-analyses, systematic reviews, narrative reviews, reports and individual studies. Grey literature was also included. We chose a narrative review approach because of substantial heterogeneity of study designs in the literature.
1119 articles of potential relevance were retained, of which 246 were included in our review. There was insufficient evidence to determine whether general practitioners with a special interest (GPwSI) in respiratory care improved the diagnosis and management of mild-to-moderate COPD. An asthma service involving GPwSI increased respiratory drug costs but reduced the costs for less specific drugs. No clear benefit has been shown for practice nurse-run asthma clinics in primary care compared with usual care in altering asthma morbidity, quality of life, lung function or medication use. Evidence to determine the effectiveness of practice nurse-run COPD clinics could not be found. Self-management education, GP review and action plans may produce short-term benefits for asthma patients, particularly those with moderate-to-severe disease, but the evidence for a similar approach to patients with mild-to-moderate COPD is equivocal. There has been poor uptake of respiratory clinical guidelines relevant to primary care - partly because most guidelines are based on moderate-to-severe disease. Spirometry programs in primary care are useful for differential diagnosis of asthma and COPD. Spirometry may alter the management of mild asthma, but there is a lack of evidence that it alters the management of COPD in primary care.
The role of primary health care in management of mild-to-moderate asthma and COPD requires further investigation using randomised controlled trials.
回顾文献,寻找针对成人轻至中度哮喘和慢性阻塞性肺疾病(COPD)初级保健管理的任何有前景的策略。
使用COPD、哮喘和初级卫生保健的“医学主题词”(MeSH)术语,我们对相关的荟萃分析、系统评价、叙述性综述、报告和个体研究进行了广泛的文献检索。灰色文献也包括在内。由于文献中研究设计存在大量异质性,我们选择了叙述性综述方法。
保留了1119篇可能相关的文章,其中246篇纳入我们的综述。没有足够的证据来确定对呼吸护理有特殊兴趣的全科医生(GPwSI)是否能改善轻至中度COPD的诊断和管理。一个涉及GPwSI的哮喘服务增加了呼吸药物成本,但降低了非特异性药物的成本。与常规护理相比,在初级保健中由执业护士管理的哮喘诊所,在改变哮喘发病率、生活质量、肺功能或药物使用方面,未显示出明显益处。未找到确定执业护士管理的COPD诊所有效性的证据。自我管理教育、全科医生复诊和行动计划可能对哮喘患者,尤其是中重度疾病患者产生短期益处,但对于轻至中度COPD患者采用类似方法的证据尚不明确。与初级保健相关的呼吸临床指南的采用情况不佳——部分原因是大多数指南基于中重度疾病。初级保健中的肺活量测定项目有助于哮喘和COPD的鉴别诊断。肺活量测定可能会改变轻度哮喘的管理,但缺乏证据表明它能改变初级保健中COPD的管理。
初级卫生保健在轻至中度哮喘和COPD管理中的作用需要通过随机对照试验进一步研究。