Fujimura I, Geraldes S M, Ito L S, Matsuda C K, de Oliveira E, Povoa M F, Sclearuc E A, Zanotto A
Departamento de Anatomia, Faculdade de Medicina de Jundiaí.
Rev Hosp Clin Fac Med Sao Paulo. 1991 Jan-Feb;46(1):14-8.
The deficiency of ascorbic acid in the diet affects the activity of lecithin cholesterol acyl-transferase enzyme and transformation of cholesterol to its main catabolic product the biliary acids. Fifteen patients with normal blood levels of cholesterol and fifteen patients with hypercholesterolemia were submitted to a comparative study as to the dietary ingestion of ascorbic acid. Besides this the presence of the varicosity of the sublingual vein--indicating hypovitaminosis C--was investigated in both groups of patients. The "t" Student test and Control-Case test of the results showed that regarding the cholesterol level there was a significant difference between the patients with hypercholesterolemia (422 +/- 116.2018 mg/100 ml) and those with normal cholesterolemia (160.73 +/- 29.5356 mg/100 ml). The ingestion of ascorbic acid in he diet of the normal cholesterolemia group was found to be significantly higher than that of patients with hypercholesterolemia. The ingestion of cholesterol was high in the group of patients with hypercholesterolemia but in comparison with other groups there was no significant difference. The varicosity of the sublingual vein was observed with significantly higher frequency (p < 0.0001) in the group of patients with hypercholesterolemia and lower ingestion of ascorbic acid.
饮食中抗坏血酸的缺乏会影响卵磷脂胆固醇酰基转移酶的活性以及胆固醇向其主要分解代谢产物胆汁酸的转化。对15名胆固醇水平正常的患者和15名高胆固醇血症患者进行了关于抗坏血酸饮食摄入的比较研究。此外，还对两组患者舌下静脉静脉曲张（提示维生素C缺乏症）的情况进行了调查。结果的t检验和对照病例检验表明，就胆固醇水平而言，高胆固醇血症患者（422±116.2018mg/100ml）与胆固醇血症正常患者（160.73±29.5356mg/100ml）之间存在显著差异。发现胆固醇血症正常组饮食中抗坏血酸的摄入量显著高于高胆固醇血症患者。高胆固醇血症患者组的胆固醇摄入量较高，但与其他组相比没有显著差异。在高胆固醇血症且抗坏血酸摄入量较低的患者组中，观察到舌下静脉静脉曲张的频率显著更高（p<0.0001）。
