Zhang Hong, Han Ting, Sun Lian-Na, Huang Bao-Kang, Chen Yu-Feng, Zheng Han-Chen, Qin Lu-Ping
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.
Phytomedicine. 2008 Aug;15(8):602-11. doi: 10.1016/j.phymed.2008.02.005. Epub 2008 Apr 21.
Gastric motor dysfunction induced by psychological stress results in many symptoms of functional dyspepsia (FD). There are a number of herbal medicines that are reported to improve gastrointestinal motor. However, the mechanisms of considerable herbal medicines are not explicit. In the present study, the effects of an essential oil (EO) extracted from Atractylodes lancea on delayed gastric emptying, gastrointestinal hormone and hypothalamic corticotropin-releasing factor (CRF) abnormalities induced by restraint stress in rats were investigated and the mechanism of the EO is also explored. Oral administration of EO for 7 days did not affect normal gastric emptying, but accelerated delayed gastric emptying induced by restraint stress in rats. The EO significantly increased the levels of motilin (MTL) and gastrin (GAS) and decreased the levels of somatostatin (SS) and CRF. The EO did not modify gastric emptying in vagotomized rats that underwent restraint stress, but antagonized delayed gastric emptying induced by intracisternal injection of CRF. These results suggest that the regulative effects of the EO on delayed gastric emptying are preformed mainly via inhibition of the release of central CRF and activation of vagal pathway, which are also involved in the release of gastrointestinal hormones such as MTL, GAS and SS.
心理应激诱导的胃运动功能障碍会导致功能性消化不良（FD）的多种症状。据报道，有多种草药可改善胃肠动力。然而，相当一部分草药的作用机制尚不明确。在本研究中，研究了从白术中提取的一种挥发油（EO）对束缚应激诱导的大鼠胃排空延迟、胃肠激素及下丘脑促肾上腺皮质激素释放因子（CRF）异常的影响，并探讨了该挥发油的作用机制。连续7天口服挥发油对正常大鼠胃排空无影响，但能加速束缚应激诱导的大鼠胃排空延迟。该挥发油显著提高了胃动素（MTL）和胃泌素（GAS）水平，降低了生长抑素（SS）和CRF水平。该挥发油对接受束缚应激的迷走神经切断大鼠的胃排空无影响，但能对抗脑池内注射CRF诱导的胃排空延迟。这些结果表明，挥发油对胃排空延迟的调节作用主要通过抑制中枢CRF释放和激活迷走神经通路来实现，这也与胃肠激素如MTL、GAS和SS的释放有关。
