Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Toon City, Ehime 791-0295, Japan.
J Ethnopharmacol. 2012 May 7;141(1):530-6. doi: 10.1016/j.jep.2012.02.031. Epub 2012 Feb 21.
The rhizomes of Atractylodes lancea DC (Compositae) are used clinically to treat gastrointestinal symptoms, including functional dyspepsia and gastroparesis, in China and Japan, but their influence and mechanism on gastrointestinal motility are not yet proven in detail.
This study examined the effects of an Atractylodes lancea extract, and isolated β-eudesmol, on gastric emptying and small intestinal motility in atropine-, dopamine-, and 5-hydroxytryptamine (5-HT)-treated mice.
The extract (500 or 1000mg/kg) and β-eudesmol (50 or 100mg/kg), as well as itopride hydrochloride (a dopamine D(2) receptor antagonist, 10 or 50mg/kg), stimulated small intestinal motility in normal mice. They inhibited reductions in gastric emptying and gastrointestinal motility induced by dopamine (1mg/kg, intraperitoneal injection, ip). The extract (1000mg/kg) and β-eudesmol (100mg/kg) inhibited the atropine-induced decrease in small intestinal motility, but not gastric emptying. Furthermore, the extract (500 or 1000mg/kg) and β-eudesmol (25, 50, or 100mg/kg) inhibited reductions in gastric emptying and small intestinal motility caused by 5-HT (4mg/kg, ip) or the 5-HT(3) receptor agonist 1-(3-chlorophenyl) biguanide (0.5mg/kg, ip), but not a 5-HT(2C) receptor agonist. These findings suggest that the extract of Atractylodes lancea and β-eudesmol may stimulate gastric emptying or small intestinal motility by inhibiting the dopamine D(2) receptor and 5-HT(3) receptor.
白术（菊科）根茎在中国和日本临床上用于治疗胃肠道症状，包括功能性消化不良和胃轻瘫，但它们对胃肠动力的影响和机制尚未详细证实。
本研究考察了白术提取物和分离出的β-桉叶醇对阿托品、多巴胺和 5-羟色胺（5-HT）处理小鼠胃排空和小肠运动的影响。
提取物（500 或 1000mg/kg）和β-桉叶醇（50 或 100mg/kg）以及盐酸伊托必利（多巴胺 D2 受体拮抗剂，10 或 50mg/kg）刺激正常小鼠小肠运动。它们抑制多巴胺（1mg/kg，腹腔注射，ip）引起的胃排空和胃肠运动减少。提取物（1000mg/kg）和β-桉叶醇（100mg/kg）抑制阿托品引起的小肠运动减少，但不抑制胃排空。此外，提取物（500 或 1000mg/kg）和β-桉叶醇（25、50 或 100mg/kg）抑制 5-HT（4mg/kg，ip）或 5-HT3 受体激动剂 1-（3-氯苯基）双胍（0.5mg/kg，ip）引起的胃排空和小肠运动减少，但不抑制 5-HT2C 受体激动剂。这些发现表明，白术提取物和β-桉叶醇可能通过抑制多巴胺 D2 受体和 5-HT3 受体刺激胃排空或小肠运动。
