Mathur Nitin, Ramasubbu Kumudha, Mann Douglas L
Baylor College of Medicine, Houston, TX, USA.
Heart Fail Clin. 2008 Apr;4(2):153-61. doi: 10.1016/j.hfc.2008.01.007.
The syndrome of heart failure is characterized by increased levels of circulating inflammatory mediators, which have been implicated in the pathogenesis of heart failure. Recently, a number of studies have suggested that statins may exert salutary effects in patients who have heart failure by virtue of their pleiotropic (non-lipid lowering) actions. This article focuses on the non-lipid lowering effects of statins, with an emphasis on the anti-inflammatory properties of these agents.
心力衰竭综合征的特征是循环炎症介质水平升高,这些介质与心力衰竭的发病机制有关。最近,一些研究表明,他汀类药物可能因其多效性(非降脂)作用而对心力衰竭患者产生有益影响。本文重点关注他汀类药物的非降脂作用,尤其强调这些药物的抗炎特性。