HLA-II类分子与多发性硬化症的关联风险及保护作用——一项芬兰家族研究

HLA class II associated risk and protection against multiple sclerosis-a Finnish family study.

作者信息

Laaksonen Mikko, Pastinen Tomi, Sjöroos Minna, Kuokkanen Satu, Ruutiainen Juhani, Sumelahti Marja Liisa, Reijonen Helena, Salonen Reijo, Wikström Juhani, Panelius Martin, Partanen Jukka, Tienari Pentti J, Ilonen Jorma

机构信息

Turku Immunology Centre and Department of Virology, University of Turku, Kiinamyllynkatu 13, FIN-20520, Turku, Finland.

出版信息

J Neuroimmunol. 2002 Jan;122(1-2):140-5. doi: 10.1016/s0165-5728(01)00456-8.

DOI:10.1016/s0165-5728(01)00456-8

PMID:11777553

Abstract

We analyzed the HLA class II haplotypes in 249 Finnish nuclear families and compared the frequencies of parental haplotypes transmitted or non-transmitted to multiple sclerosis (MS) patients. The most important predisposing haplotype was DRB115-DQB10602 (P<10(-6)) as expected and a weak predisposing effect of DRB104-DQB10302 was revealed after the elimination of DRB115-DQB10602. HLA-DRB101-DQB10501 and DRB113-DQB10603 were negatively associated with MS in transmission disequilibrium test, but only the DRB113-DQB10603 association remained significant (P=0.008) after the elimination of DRB115-DQB10602 haplotypes. Based on this study HLA class II haplotypes exhibit both predisposing and protective effects in MS.

摘要

我们分析了249个芬兰核心家庭中的HLA II类单倍型，并比较了传递给或未传递给多发性硬化症（MS）患者的亲代单倍型的频率。正如预期的那样，最重要的易感单倍型是DRB115 - DQB10602（P<10^(-6)），并且在排除DRB115 - DQB10602后，发现DRB104 - DQB10302有微弱的易感作用。在传递不平衡检验中，HLA - DRB101 - DQB10501和DRB113 - DQB10603与MS呈负相关，但在排除DRB115 - DQB10602单倍型后，只有DRB113 - DQB10603的相关性仍然显著（P = 0.008）。基于这项研究，HLA II类单倍型在MS中既表现出易感作用，也表现出保护作用。