RGS4基因多态性与重度抑郁症患者对电休克治疗的反应
RGS4 polymorphism and response to electroconvulsive therapy in major depressive disorder.
作者信息
Huuhka Kaija, Kampman Olli, Anttila Sami, Huuhka Martti, Rontu Riikka, Mattila Kari M, Hurme Mikko, Lehtimäki Terho, Leinonen Esa
机构信息
University of Tampere, Medical School, Department of Psychiatry, Tampere University Hospital, Tampere, Finland.
出版信息
Neurosci Lett. 2008 May 23;437(1):25-8. doi: 10.1016/j.neulet.2008.03.065. Epub 2008 Mar 28.
We studied the association between RGS4 (rs951436) polymorphism and treatment response in electroconvulsive therapy (ECT) as well as risk of treatment-resistant depression. The study sample consisted of 119 patients with major depressive disorder (MDD) and 384 healthy control subjects. RGS4 polymorphism was not associated with treatment response in ECT or risk of MDD. According to the present data, the impact of RGS4 genotype is not decisive in major depressive disorder. The results provide preliminary data on the impact of RGS4 polymorphism in treatment response in ECT.
我们研究了RGS4（rs951436）基因多态性与电休克治疗（ECT）的治疗反应以及难治性抑郁症风险之间的关联。研究样本包括119例重度抑郁症（MDD）患者和384名健康对照者。RGS4基因多态性与ECT的治疗反应或MDD风险无关。根据目前的数据，RGS4基因型在重度抑郁症中并非起决定性作用。这些结果为RGS4基因多态性对ECT治疗反应的影响提供了初步数据。
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