Anttila Sami, Huuhka Kaija, Huuhka Martti, Illi Ari, Rontu Riikka, Leinonen Esa, Lehtimäki Terho
University of Tampere Medical School, University of Tampere, Tampere, Finland.
Pharmacogenomics J. 2008 Apr;8(2):113-6. doi: 10.1038/sj.tpj.6500468. Epub 2007 Aug 14.
Several lines of evidence suggest that catechol-O-methyltransferase (COMT) may be associated with treatment response in depression. We conducted a study on 119 patients with treatment-refractory depression admitted consecutively for electroconvulsive therapy (ECT). The COMT high/high genotype leads to a higher enzyme activity and thus lowers dopaminergic activity in the prefrontal cortex. In the present sample, those homozygous to high-active allele of COMT responded significantly more frequently to ECT.
多项证据表明，儿茶酚-O-甲基转移酶（COMT）可能与抑郁症的治疗反应有关。我们对119例因难治性抑郁症连续入院接受电休克治疗（ECT）的患者进行了一项研究。COMT高/高基因型导致更高的酶活性，从而降低前额叶皮质中的多巴胺能活性。在本样本中，那些COMT高活性等位基因纯合子对ECT的反应明显更频繁。
