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中心性浆液性脉络膜视网膜病变

Central serous chorioretinopathy.

作者信息

Marcuson Jeremy, Riley Thomas

机构信息

Spokane Veterans Affairs Medical Center, Spokane, Washington 99205, USA.

出版信息

Optometry. 2008 May;79(5):241-51. doi: 10.1016/j.optm.2007.02.024.

DOI:10.1016/j.optm.2007.02.024
PMID:18436164
Abstract

BACKGROUND

Central serous chorioretinopathy is a condition typically affecting young adults between 25 and 50 years of age. It is predominating in type A personality trait men. Central serous chorioretinopathy is defined clinically as a detachment of the sensory retina that is commonly unilateral but can also be bilateral. Laser photocoagulation has been used widely with central serous chorioretinopathy to prevent recurrence and to speed recovery time. Photodynamic therapy is emerging as a potential treatment for chronic central serous chorioretinopathy. The prognosis for resolution and visual recovery for patients with central serous chorioretinopathy is excellent. Approximately 95% of patients with central serous chorioretinopathy will recover to a final visual acuity of 20/30.

CASE REPORTS

Patient 1 was a 57-year-old man who reported to the clinic with a complaint of central scotoma involving the left eye. He also had a decrease in best-corrected visual acuity of 20/30 in the left eye. Idiopathic central serous chorioretinopathy was diagnosed, and observation was the management choice. At the 6-month follow-up, the patient's left eye visual acuity had returned to 20/20. Patient 2 was a 63-year-old man who reported to the clinic with decreased central vision of the left eye. His best-corrected visual acuity in that eye was 20/40. This was an unusual case because of the patient's age and the risk of macular degeneration. With fluorescein angiography and optical coherence tomography, the diagnosis of central serous chorioretinopathy was confirmed. At the 10-month follow-up the patient's acuity had returned to 20/20 in the left eye. Patient 3 was a 59-year-old man who reported to the clinic with decreased vision in the left eye. His best-corrected visual acuity was 20/60 in that eye. He is a kidney transplant recipient and was taking 60 mg of prednisone. The patient was found to have steroid-induced central serous chorioretinopathy. Observation was the management of choice for several months without resolution. Focal laser photocoagulation was performed at the 6-month follow-up, which did not help, and his ultimate visual acuity in the left eye was 20/400. He returned to the clinic 3 years later with the same complaint in his right eye. The patient was again found to have steroid-induced central serous chorioretinopathy but in the right eye, with a best-corrected visual acuity of 20/30. Because of the failure of photocoagulation in the left eye, observation was the chosen management option. The central serous chorioretinopathy did not resolve, and because of this it was decided that the patient's nephrologist be contacted to suggest a decrease in the patient's oral prednisone dose. The nephrologist decreased his prednisone from 60 mg daily to 5 mg daily. With this change, the patient's visual acuity stabilized at 20/25. The central serous chorioretinopathy was still present but without subjective visual complaints.

CONCLUSION

Central serous chorioretinopathy is a condition that normally affects type A personality trait men. Also, patients taking any type of corticosteroids must be watched closely for the development of central serous chorioretinopathy. There is no good course for treatment, with observation being the best management choice. Photodynamic therapy may become the treatment choice for patients with chronic central serous chorioretinopathy, but more studies on the use of photodynamic therapy need to be completed.

摘要

背景

中心性浆液性脉络膜视网膜病变是一种典型影响25至50岁青壮年的疾病。在A型人格特质男性中更为常见。中心性浆液性脉络膜视网膜病变在临床上定义为感觉视网膜脱离,通常为单侧,但也可为双侧。激光光凝术已广泛用于中心性浆液性脉络膜视网膜病变,以预防复发并加快恢复时间。光动力疗法正在成为慢性中心性浆液性脉络膜视网膜病变的一种潜在治疗方法。中心性浆液性脉络膜视网膜病变患者的视力恢复和视觉预后良好。约95%的中心性浆液性脉络膜视网膜病变患者最终视力可恢复至20/30。

病例报告

患者1是一名57岁男性,因左眼中心暗点到诊所就诊。其左眼最佳矫正视力也降至20/30。诊断为特发性中心性浆液性脉络膜视网膜病变,治疗选择为观察。在6个月随访时,患者左眼视力恢复至20/20。患者2是一名63岁男性,因左眼中心视力下降到诊所就诊。该眼最佳矫正视力为20/40。由于患者年龄及黄斑变性风险,这是一例不寻常病例。通过荧光素血管造影和光学相干断层扫描,确诊为中心性浆液性脉络膜视网膜病变。在10个月随访时,患者左眼视力恢复至20/20。患者3是一名59岁男性,因左眼视力下降到诊所就诊。该眼最佳矫正视力为20/60。他是一名肾移植受者,正在服用60毫克泼尼松。该患者被诊断为类固醇性中心性浆液性脉络膜视网膜病变。观察数月病情未缓解。在6个月随访时进行了局部激光光凝术,但无效果,其左眼最终视力为20/400。3年后他因右眼同样症状再次到诊所就诊。该患者右眼再次被诊断为类固醇性中心性浆液性脉络膜视网膜病变,最佳矫正视力为20/30。由于左眼光凝术失败,观察为首选治疗方案。中心性浆液性脉络膜视网膜病变未缓解,因此决定联系患者的肾病科医生,建议减少患者口服泼尼松剂量。肾病科医生将其泼尼松剂量从每日60毫克减至每日5毫克。随着这一变化,患者视力稳定在20/25。中心性浆液性脉络膜视网膜病变仍然存在,但无主观视觉症状。

结论

中心性浆液性脉络膜视网膜病变通常影响A型人格特质男性。此外,必须密切观察服用任何类型皮质类固醇的患者是否发生中心性浆液性脉络膜视网膜病变。目前没有很好的治疗方案,观察是最佳管理选择。光动力疗法可能成为慢性中心性浆液性脉络膜视网膜病变患者的治疗选择,但需要完成更多关于光动力疗法应用的研究。

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