Wolf Patrick S, Flum David R, Tanas Munir R, Rubin Brian P, Mann Gary N
University of Washington Medical Center, Seattle, WA 98195, USA.
Am J Surg. 2008 Sep;196(3):407-12. doi: 10.1016/j.amjsurg.2007.07.029. Epub 2008 Apr 24.
Epithelioid sarcoma is a rare sarcoma with a high local recurrence rate that frequently metastasizes to lymph nodes. We reviewed our experience with adjuvant therapy in patients with this disease.
Between 1990 and 2003, we treated 11 patients with epithelioid sarcoma. Patient, tumor, and treatment characteristics were analyzed, and effect of treatment on survival was evaluated by the Kaplan-Meier method.
Nine men and 2 women were treated. Tumors presented on the trunk, the upper extremities, and the lower extremities. Five patients developed nodal disease. All patients underwent surgery for the primary tumor, and 7 patients had nodal evaluation. Ten patients underwent adjuvant chemotherapy, and 9 underwent radiotherapy. Recurrence developed in 9 patients. Five-year disease-free and overall survival rates were 46% and 65%, respectively. Chemotherapy and radiation therapy did not impact disease-free survival.
Although surgery remains the primary treatment modality, multi-institutional trials are needed to develop more effective adjuvant therapy for patients with epithelioid sarcoma.
上皮样肉瘤是一种罕见的肉瘤，局部复发率高，且常转移至淋巴结。我们回顾了我们在该病患者辅助治疗方面的经验。
1990年至2003年间，我们治疗了11例上皮样肉瘤患者。分析了患者、肿瘤及治疗特征，并采用Kaplan-Meier法评估治疗对生存的影响。
治疗了9名男性和2名女性。肿瘤出现在躯干、上肢和下肢。5例患者出现淋巴结病变。所有患者均接受了原发性肿瘤手术，7例患者进行了淋巴结评估。10例患者接受了辅助化疗，9例接受了放疗。9例患者出现复发。五年无病生存率和总生存率分别为46%和65%。化疗和放疗对无病生存无影响。
尽管手术仍然是主要的治疗方式，但需要进行多机构试验，以开发出针对上皮样肉瘤患者更有效的辅助治疗方法。
