Whyman C A, McDonald S A, Zoutman D
Can J Infect Control. 1991 Winter;6(4):91-3.
It has been suggested that serial usage of automatic endoscope washer-disinfectors may result in dilution of glutaraldehyde (used as the disinfectant in these machines). However, there are no published data available to confirm this possibility. The authors therefore undertook a study to determine the extent of glutaraldehyde dilution occurring during repeated cycles of an endoscope washer-disinfector over a 14 day period. It was found that the concentration of glutaraldehyde in the endoscope washer-disinfector consistently fell with increasing numbers of wash cycles, and that after 60 cycles the concentration of glutaraldehyde fell below the recommended minimum effective concentration of 1%. Users of automatic endoscope washer-disinfectors should be aware of the potential for dilution of glutaraldehyde in these machines. It is the number of washer-disinfector cycles, and not only the elapsed time since activation of the glutaraldehyde, which determines the frequency with which the glutaraldehyde solution must be replenished. Test kits are now available to measure glutaraldehyde concentration chemically, and may be useful in a quality control program of serial testing of glutaraldehyde concentrations in the endoscope washer-disinfector.
有人提出，连续使用自动内镜清洗消毒机可能会导致戊二醛（这些机器中用作消毒剂）被稀释。然而，目前尚无公开数据证实这种可能性。因此，作者进行了一项研究，以确定在14天内，内镜清洗消毒机重复运行周期中戊二醛的稀释程度。研究发现，随着清洗周期数的增加，内镜清洗消毒机中戊二醛的浓度持续下降，且在60个周期后，戊二醛浓度降至推荐的最低有效浓度1%以下。自动内镜清洗消毒机的使用者应意识到这些机器中戊二醛有被稀释的可能性。决定戊二醛溶液必须补充的频率的是清洗消毒机的运行周期数，而不仅仅是自戊二醛激活以来所经过的时间。现在有测试试剂盒可通过化学方法测量戊二醛浓度，这可能有助于在内镜清洗消毒机中对戊二醛浓度进行连续检测的质量控制程序。
