Jou Yeong-Chin, Lien Fang-Chieh, Cheng Ming-Chin, Shen Cheng-Huang, Lin Chang-Te, Chen Pi-Che
Department of Urology, Chiayi Christian Hospital, Chiayi, Taiwan, R.O.C.
J Chin Med Assoc. 2008 Apr;71(4):218-20. doi: 10.1016/S1726-4901(08)70108-4.
Hemorrhagic cystitis is a complication of systemic lupus erythematosus and is also a common side effect after cyclophosphamide therapy. Intractable hemorrhagic cystitis is not unusual and may be a life-threatening condition; it has no effective noninvasive treatment at present. We report a case of hemorrhagic cystitis with intractable refractory bleeding that occurred in a 40-year-old woman after cyclophosphamide treatment for systemic lupus erythematosus. The hemorrhage was resistant to various therapies but resolved after hyperbaric oxygen therapy. There was no recurrent hematuria after hyperbaric oxygen therapy during 6 months of follow-up.
出血性膀胱炎是系统性红斑狼疮的一种并发症，也是环磷酰胺治疗后的常见副作用。难治性出血性膀胱炎并不罕见，可能是一种危及生命的疾病；目前尚无有效的非侵入性治疗方法。我们报告一例40岁女性在接受环磷酰胺治疗系统性红斑狼疮后发生的伴有难治性出血的出血性膀胱炎。出血对各种治疗均有抵抗，但在高压氧治疗后得到缓解。在6个月的随访期间，高压氧治疗后未再出现血尿。
