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Willis覆膜支架治疗颅内动脉瘤栓塞术后复发的可行性及疗效

The feasibility and efficacy of treatment with a Willis covered stent in recurrent intracranial aneurysms after coiling.

作者信息

Li M-H, Zhu Y-Q, Fang C, Wang W, Zhang P-L, Cheng Y-S, Tan H-Q, Wang J-B

机构信息

Department of Diagnostic and Interventional Radiology, Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

出版信息

AJNR Am J Neuroradiol. 2008 Aug;29(7):1395-400. doi: 10.3174/ajnr.A1096. Epub 2008 Apr 24.

Abstract

BACKGROUND AND PURPOSE

Aneurysm recurrence is an innate problem after coiling, and the recurrence rate is higher in complicated aneurysms. We evaluated the feasibility and efficacy of using the Willis covered stent in treating recurrent aneurysms after coil embolization.

MATERIALS AND METHODS

Eight aneurysms in 8 patients treated with detachable coils had confirmed recurrent aneurysms: 3 giant, 1 large, 1 dissecting, and 3 small wide-necked. The recurrent aneurysms involved C3 in 1 patient, C4 in 1, C7 in 5, and V4 in 1. A total of 11 covered stents were implanted into 8 target arteries. Follow-up angiography was performed 1-16 months after the procedure. Clinical follow-up data were collected and retrospectively analyzed, grading as fully recovered, improved, unchanged, or aggravated.

RESULTS

Willis covered stent placement succeeded technically in all of the aneurysms. No technique-related adverse event occurred. Total occlusion was achieved immediately in 6 aneurysms, and a small endoleak was observed in 2 aneurysms. No mortality or morbidity occurred during or after the procedures, including during the follow-up period. Follow-up angiograms revealed that all 8 of the recurrent aneurysms were completely isolated, and 8 parent vessels kept patency, except 1 with mild stenosis. Clinical neurologic symptoms fully resolved in 5 patients, improved in 1, and were unchanged in 2 at the end of the follow-up period.

CONCLUSIONS

In this small study with a middle-term follow-up, the Willis covered stent was used safely and effectively to occlude recurred aneurysms after coiling. Longer-term follow-up and additional clinical experience are needed to fully determine the safety and efficacy of the device.

摘要

背景与目的

动脉瘤复发是栓塞治疗后固有的问题,复杂动脉瘤的复发率更高。我们评估了使用Willis覆膜支架治疗弹簧圈栓塞后复发动脉瘤的可行性和疗效。

材料与方法

8例接受可脱性弹簧圈治疗的患者共8个动脉瘤被证实复发:3个巨大动脉瘤、1个大型动脉瘤、1个夹层动脉瘤和3个小型宽颈动脉瘤。复发动脉瘤累及C3段1例、C4段1例、C7段5例、V4段1例。共向8条靶血管植入11枚覆膜支架。术后1至16个月进行随访血管造影。收集临床随访数据并进行回顾性分析,分为完全恢复、改善、不变或加重。

结果

所有动脉瘤Willis覆膜支架置入技术均成功。未发生与技术相关的不良事件。6个动脉瘤立即实现完全闭塞,2个动脉瘤观察到小的内漏。手术期间及术后,包括随访期间均未发生死亡或并发症。随访血管造影显示,所有8个复发动脉瘤均被完全隔绝,8条载瘤血管保持通畅,仅1条有轻度狭窄。随访期末,5例患者临床神经症状完全缓解,1例改善,2例不变。

结论

在这项中期随访的小型研究中,Willis覆膜支架安全有效地用于闭塞弹簧圈栓塞后复发的动脉瘤。需要更长时间的随访和更多临床经验来充分确定该装置的安全性和疗效。

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