Zhang Xiaomin, He Mei-An, Cheng Longxian, Zhou Li, Zeng Hesong, Wang Jing, Wang Feng, Chen Ying, Hu Frank B, Wu Tangchun
Institute of Occupational Medicine and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Clin Chem. 2008 Jun;54(6):1046-52. doi: 10.1373/clinchem.2007.101451. Epub 2008 Apr 24.
Several studies have suggested an association between antibody to human heat shock protein 60 (anti-Hsp60) and coronary atherosclerosis, but the results have been inconsistent. The aim of this study was to investigate the association between anti-Hsp60 and coronary heart disease (CHD) and to determine whether anti-Hsp60, hypertension, and diabetes have joint effects on CHD risk.
We measured the concentrations of anti-Hsp60 in 1003 CHD patients and 1003 age- and sex-matched control subjects without CHD events.
Concentrations of anti-Hsp60 were significantly higher in CHD patients than in controls. Increasing concentrations of anti-Hsp60 were significantly associated with higher risk of CHD (P for trend <0.0001) and with increasing severity of CHD as assessed by number of diseased vessels detected with angiography [odds ratio (OR) 3.67, 95% CI 1.56-8.64, P = 0.003] after multivariate adjustment for traditional CHD risk factors. There were strong joint effects of high concentrations of anti-Hsp60 and hypertension (OR 5.17, 95% CI 3.95-6.75, P < 0.0001) and diabetes (OR 6.49, 95% CI 4.52-9.33, P < 0.0001) on CHD risk; simultaneous occurrence of high anti-Hsp60 concentrations, hypertension, and diabetes conferred a dramatically higher risk of CHD (OR 20.99, 95% CI 12.50-35.24, P < 0.0001) in multivariate analyses.
Anti-Hsp60 is independently associated with CHD risk, and a combination of high anti-Hsp60, hypertension, and diabetes is particularly detrimental for CHD risk.
多项研究提示人类热休克蛋白60抗体（抗Hsp60）与冠状动脉粥样硬化之间存在关联，但结果并不一致。本研究旨在探讨抗Hsp60与冠心病（CHD）之间的关联，并确定抗Hsp60、高血压和糖尿病是否对CHD风险具有联合作用。
我们测量了1003例CHD患者和1003例年龄及性别匹配的无CHD事件对照者的抗Hsp60浓度。
CHD患者的抗Hsp60浓度显著高于对照组。抗Hsp60浓度升高与CHD风险增加显著相关（趋势P<0.0001），并且在对传统CHD危险因素进行多变量调整后，与通过血管造影检测到的病变血管数量评估的CHD严重程度增加相关[比值比（OR）3.67，95%可信区间（CI）1.56 - 8.64，P = 0.003]。高浓度抗Hsp60与高血压（OR 5.17，95% CI 3.95 - 6.75，P < 0.0001）和糖尿病（OR 6.49，95% CI 4.52 - 9.33，P < 0.0001）对CHD风险具有强烈的联合作用；在多变量分析中，高抗Hsp60浓度、高血压和糖尿病同时出现会使CHD风险显著升高（OR 20.99，95% CI 12.50 - 35.24，P < 0.0001）。
抗Hsp60与CHD风险独立相关，高抗Hsp60、高血压和糖尿病的组合对CHD风险尤其有害。
