Department of Ophthalmology, Center for Sensory Organ Diseases, Sannoh Medical Center, Chiba, Japan.
Eye (Lond). 2009 Apr;23(4):884-9. doi: 10.1038/eye.2008.119. Epub 2008 Apr 25.
To examine the early differences in the thicknesses of the macula and retinal nerve fibre layer (RNFL) by Stratus optical coherence tomography in patients with diabetes mellitus.
Thirty-one normal participants without any optic nerve and retinal diseases (control), 45 diabetic patients without diabetic retinopathy (NDR), and 24 diabetic patients with preproliferative diabetic retinopathy (PPDR), who did not have clinically significant macular oedema, were used for the macular thickness measurements. Thirty control participants, 45 patients classified as NDR, and 22 patients classified as PPDR were used for the RNFL thickness measurements.
In patients with NDR, macula was significantly thinner than that of control eyes. In patients with PPDR, the mean RNFL thickness was significantly thinner but the macula was thicker than that of control eyes. In women with NDR, the macula was significantly thinner than that of men with NDR and that of normal women. In men with PPDR, the RNFL thickness was significantly thinner than that of the control eyes.
At the early stage of diabetic retinopathy, the maculas and RNFL thicknesses are altered. The macular and RNFL thicknesses are different in men and women.
用 Stratus 光相干断层扫描仪观察糖尿病患者黄斑和视网膜神经纤维层（RNFL）厚度的早期差异。
31 名无任何视神经和视网膜疾病的正常参与者（对照组），45 名无糖尿病性视网膜病变的糖尿病患者（NDR 组），24 名患有早期增生性糖尿病性视网膜病变（PPDR）但无临床显著黄斑水肿的糖尿病患者，用于黄斑厚度测量。30 名对照组参与者、45 名 NDR 患者和 22 名 PPDR 患者用于测量 RNFL 厚度。
在 NDR 患者中，黄斑明显比对照组的薄。在 PPDR 患者中，平均 RNFL 厚度明显变薄，但黄斑比对照组的厚。在 NDR 的女性中，黄斑明显比 NDR 的男性和正常女性薄。在 PPDR 的男性中，RNFL 厚度明显比对照组的薄。
在糖尿病性视网膜病变的早期阶段，黄斑和 RNFL 厚度发生改变。男性和女性的黄斑和 RNFL 厚度不同。
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