Molander Gary A, Canturk Belgin
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.
Org Lett. 2008 Jun 5;10(11):2135-8. doi: 10.1021/ol800532p. Epub 2008 Apr 26.
A wide variety of alkoxymethyltrifluoroborate substrates were prepared via SN2 displacement of potassium bromomethyltrifluoroborate with various alkoxides in excellent yields. These alkoxymethyltrifluoroborates were effectively cross-coupled with several aryl chlorides. This method provides a unique dissonant disconnect that allows greater flexibility in the design of new and improved synthetic pathways.
通过溴甲基三氟硼酸钾与各种醇盐的SN2取代反应,以优异的产率制备了多种烷氧基甲基三氟硼酸盐底物。这些烷氧基甲基三氟硼酸盐能与几种芳基氯有效地进行交叉偶联。该方法提供了一种独特的不协调切断方式,在设计新的和改进的合成途径时具有更大的灵活性。