Roy and Diana A. Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.
Org Lett. 2012 Sep 7;14(17):4458-61. doi: 10.1021/ol301955s. Epub 2012 Aug 29.
Seven potassium Boc-protected secondary aminomethyltrifluoroborates were prepared in a standardized two-step process. The Suzuki-Miyaura cross-coupling reaction was studied with this new class of nucleophiles, and a large variety of aryl and hetaryl chlorides provided the desired products in good to excellent yields, thereby allowing easy access to secondary aminomethyl substructures.
七种 Boc 保护的钾基仲氨甲基三氟硼酸盐通过标准化的两步法制备。用这一新类亲核试剂研究了 Suzuki-Miyaura 交叉偶联反应,各种芳基和杂芳基氯化物以良好至优异的产率得到了所需产物,从而可以轻松获得仲氨甲基亚结构。