编码肝细胞核因子-1α的HNF1A基因多态性与C反应蛋白相关。
Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
作者信息
Reiner Alexander P, Barber Mathew J, Guan Yongtao, Ridker Paul M, Lange Leslie A, Chasman Daniel I, Walston Jeremy D, Cooper Gregory M, Jenny Nancy S, Rieder Mark J, Durda J Peter, Smith Joshua D, Novembre John, Tracy Russell P, Rotter Jerome I, Stephens Matthew, Nickerson Deborah A, Krauss Ronald M
机构信息
University of Washington, Department of Epidemiology, Seattle, WA 98195, USA.
出版信息
Am J Hum Genet. 2008 May;82(5):1193-201. doi: 10.1016/j.ajhg.2008.03.017. Epub 2008 Apr 24.
Abstract
Data from the Pharmacogenomics and Risk of Cardiovascular Disease (PARC) study and the Cardiovascular Health Study (CHS) provide independent and confirmatory evidence for association between common polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha and plasma C-reactive protein (CRP) concentration. Analyses with the use of imputation-based methods to combine genotype data from both studies and to test untyped SNPs from the HapMap database identified several SNPs within a 5 kb region of HNF1A intron 1 with the strongest evidence of association with CRP phenotype.
摘要
来自药物基因组学与心血管疾病风险（PARC）研究及心血管健康研究（CHS）的数据，为编码肝细胞核因子-1α的HNF1A基因常见多态性与血浆C反应蛋白（CRP）浓度之间的关联提供了独立且相互印证的证据。运用基于归因的方法对两项研究的基因型数据进行合并，并对HapMap数据库中的未分型单核苷酸多态性（SNP）进行检测，分析结果确定了HNF1A基因内含子1的5 kb区域内有多个SNP，它们与CRP表型关联的证据最为充分。
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