Shin Dayeon, Lee Kyung Won
Department of Food and Nutrition, Inha University, Incheon, South Korea.
Department of Home Economics Education, Korea National University of Education, Cheongju-si, South Korea.
Front Nutr. 2022 Jul 7;9:900867. doi: 10.3389/fnut.2022.900867. eCollection 2022.
Epidemiological studies have demonstrated the inverse association between the intake of fruits and vegetables and inflammation. However, the mechanisms by which inflammation-related genes interact with fruit and vegetable intake and the role of these combinations in inflammation remain unclear. Therefore, we assessed the effect of interactions between fruit and vegetable intake and the hepatic nuclear factor 1 alpha () genetic variants on the C-reactive protein (CRP) levels. Baseline data from the Ansan and Ansung Cohort Study of the Korean Genome and Epidemiology Study (KoGES) were used. A total of 7,634 participants (3,700 men and 3,934 women) were included in the analyses. Fruit and vegetable intake was assessed using semi-quantitative food frequency questionnaire data. Genotyping information for was extracted from the Affymetrix Genome-Wide Human SNP array 5.0. Inflammation was determined after overnight fasting by measuring CRP levels using automated analyzers. Multivariable logistic regression was used to estimate the adjusted odds ratio (AOR) with a 95% confidence interval (CI). In the fully adjusted model, men and women with the GG genotype of HNF1A rs2393791 and high fruit intake had lower odds of elevated CRP levels compared to those with the AA genotype and low fruit intake (AOR 0.50, 95% CI 0.38-0.67; AOR 0.73, 95% CI 0.55-0.97, respectively). Men and women with the rs2393791 GG genotype and high vegetable intake had lower odds of having elevated CRP levels compared to those with the AA genotype and low fruit intake (AOR 0.57, 95% CI 0.43-0.75; AOR 0.65, 95% CI 0.49-0.86, respectively). Men and women with the GG genotype and high total fruit and vegetable intake had lower odds of having elevated CRP levels. These findings indicate that fruit and vegetable intake interacts with genetic polymorphisms, consequently influencing the inflammation levels.
流行病学研究已证实水果和蔬菜摄入量与炎症之间存在负相关。然而，炎症相关基因与水果和蔬菜摄入量相互作用的机制以及这些组合在炎症中的作用仍不清楚。因此，我们评估了水果和蔬菜摄入量与肝细胞核因子1α（HNF1A）基因变异之间的相互作用对C反应蛋白（CRP）水平的影响。我们使用了韩国基因组与流行病学研究（KoGES）中的安山和安城队列研究的基线数据。分析共纳入7634名参与者（3700名男性和3934名女性）。水果和蔬菜摄入量通过半定量食物频率问卷数据进行评估。HNF1A的基因分型信息从Affymetrix全基因组人类SNP阵列5.0中提取。在空腹过夜后，使用自动分析仪测量CRP水平来确定炎症情况。多变量逻辑回归用于估计调整后的比值比（AOR）及其95%置信区间（CI）。在完全调整模型中，与AA基因型且水果摄入量低的人相比，HNF1A rs2393791的GG基因型且水果摄入量高的男性和女性CRP水平升高的几率较低（AOR分别为0.50，95%CI为0.38 - 0.67；AOR为0.73，95%CI为0.55 - 0.97）。与AA基因型且水果摄入量低的人相比，rs2393791的GG基因型且蔬菜摄入量高的男性和女性CRP水平升高的几率较低（AOR分别为0.57，95%CI为0.43 - 0.75；AOR为0.65，95%CI为0.49 - 0.86）。GG基因型且水果和蔬菜总摄入量高的男性和女性CRP水平升高的几率较低。这些发现表明水果和蔬菜摄入量与HNF1A基因多态性相互作用，从而影响炎症水平。
