Mjös O D, Faergeman O
Scand J Clin Lab Invest. 1975 Nov;35(7):645-8.
The possible effect of high concentrations of plasma triglycerides on arterial oxygen tension was investigated in rats by infusion of lymph chylomicrons or a soybean oil emulsion (Intralipid). Mean triglyceride concentrations were raised from 130 to 1454 mg/100 ml without statistically significant change in arterial oxygen tension, oxygen saturation, carbon dioxide tension, or pH. The small reduction in arterial oxygen tension, content, or saturation observed in earlier studies may have been due to inadequate stabilization of fat emulsion then available for intravenous use. The present data suggest that high concentrations of plasma triglycerides produced by infusion of chylomicrons or Intralipid do not affect arterial blood gases in the normal rat.
通过向大鼠输注淋巴乳糜微粒或大豆油乳剂(英脱利匹特),研究了高浓度血浆甘油三酯对动脉血氧张力的可能影响。甘油三酯平均浓度从130mg/100ml升至1454mg/100ml,而动脉血氧张力、氧饱和度、二氧化碳张力或pH值无统计学显著变化。早期研究中观察到的动脉血氧张力、含量或饱和度的轻微降低,可能是由于当时可供静脉使用的脂肪乳剂稳定性不足所致。目前的数据表明,输注乳糜微粒或英脱利匹特产生的高浓度血浆甘油三酯不会影响正常大鼠的动脉血气。