Nazer J, Cifuentes L, Ruiz G
Departamento de Obstetricia y Ginecología, Facultad de Medicina, Hospital Clínico, Universidad de Chile.
Rev Chil Pediatr. 1991 Jan-Feb;62(1):37-44.
The incidence of 50 congenital malformations detected among 106,457 consecutive deliveries, in 8 chilean maternities participating in ECLAMC (Latin American Study for Congenital Malformations) is presented. The global incidence of congenital malformations was 2.97 for every 100 newborn infants. 2.92% in live borns and 8.54% in stillborns respectively. The mortality among the whole live borns of this series was of 0.93%. The incidence of congenital malformations in chilean maternities was compared with the rest of ECLAMC and significant differences were found in many of them, being higher in some problems where more complex diagnostic methods are required and were available, as is the case with congenital heart disease (23.85% vs. 9.72%) and renal agenesia (2.07% vs. 0.6%). In other types of more obvious abnormalities there were differences which could be eventually attributable to genetic or environmental factors.
本文呈现了参与拉丁美洲先天性畸形研究（ECLAMC）的8家智利产科机构中，在106457例连续分娩中检测出的50例先天性畸形的发生率。先天性畸形的总体发生率为每100例新生儿中有2.97例。活产儿中的发生率为2.92%，死产儿中的发生率为8.54%。该系列全部活产儿的死亡率为0.93%。将智利产科机构中先天性畸形的发生率与ECLAMC其他地区进行了比较，发现其中许多存在显著差异，在一些需要更复杂诊断方法且有相应诊断手段的问题中发生率更高，如先天性心脏病（23.85%对9.72%）和肾缺如（2.07%对0.6%）。在其他类型更明显的异常情况中也存在差异，最终可能归因于遗传或环境因素。
