[核医学成像：新型放射性示踪剂与未来技术]

[Nuclear medicine imaging: new radiotracers and future techniques].

作者信息

Semah F

机构信息

Laboratoire de médecine nucléaire et de recherche biomédicale, service hospitalier Frédéric-Joliot, institut d'imagerie biomédicale, commissariat à l'énergie atomique, 4, place du Général-Leclerc, 91401 Orsay cedex, France.

出版信息

Neurochirurgie. 2008 May;54(3):231-5. doi: 10.1016/j.neuchi.2008.02.035. Epub 2008 Apr 28.

DOI:10.1016/j.neuchi.2008.02.035

PMID:18440564

Abstract

Nuclear medicine imaging is based upon positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging. PET and SPECT are widely used in patients with medically refractory partial epilepsy. For clinical purposes, PET is performed using FDG and SPECT is performed using perfusion agents. PET is also used to better understand the pathophysiological mechanisms of epilepsies. New radiotracers are available for PET and SPECT imaging such as (18)F-fluoro-L-Dopa and (123)I-FP-CIT and others are under development. In addition, there are currently new methodological developments combining techniques such as SPECT associated with computed tomography and in the near future PET combined with MRI. This progress will improve the performance of nuclear medicine imaging techniques.

摘要

核医学成像基于正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）成像。PET和SPECT广泛应用于药物难治性部分性癫痫患者。出于临床目的，PET使用氟代脱氧葡萄糖（FDG）进行，SPECT使用灌注剂进行。PET还用于更好地理解癫痫的病理生理机制。有新的放射性示踪剂可用于PET和SPECT成像，如（18）F-氟-L-多巴和（123）I-FP-CIT，其他的也正在研发中。此外，目前有新的方法学进展，将SPECT与计算机断层扫描等技术相结合，在不久的将来PET将与MRI相结合。这一进展将提高核医学成像技术的性能。