Semler Oliver, Fricke Oliver, Vezyroglou Katharina, Stark Christina, Stabrey Angelika, Schoenau Eckhard
Children's Hospital, University of Cologne, Cologne, Germany.
Clin Rehabil. 2008 May;22(5):387-94. doi: 10.1177/0269215507080763.
To evaluate the effect of whole body vibration on the mobility of long-term immobilized children and adolescents with a severe form of osteogenesis imperfecta. Osteogenesis imperfecta is a hereditary primary bone disorder with a prevalence from 1 in 10000 to 1 in 20000 births. Most of these children are suffering from long-term immobilization after recurrent fractures. Due to the immobilization they are affected by loss of muscle (sarcopenia) and secondary loss of bone mass.
Whole body vibration was applied to eight children and adolescents (osteogenesis imperfecta type 3, N=5; osteogenesis imperfecta type 4, N=3) over a period of six months.
Whole body vibration was applied by a vibrating platform (Galileo Systems) constructed on a tilting-table. Success of treatment was assessed by measuring alterations of the tilting-angle and evaluating the mobility (Brief Assessment of Motor Function). All individuals were characterized by improved muscle force documented by an increased tilting-angle (median = 35 degrees) or by an increase in ground reaction force (median at start=30.0 [N/kg] (14.48-134.21); median after six months = 146.0 [N/kg] (42.46-245.25).
Whole body vibration may be a promising approach to improve mobility in children and adolescents severely affected with osteogenesis imperfecta.
评估全身振动对患有严重型成骨不全症的长期制动儿童和青少年活动能力的影响。成骨不全症是一种遗传性原发性骨病，发病率为每10000至20000例出生中有1例。这些儿童中的大多数在反复骨折后长期制动。由于制动，他们受到肌肉流失（肌肉减少症）和继发性骨质流失的影响。
对8名儿童和青少年（3型成骨不全症，N = 5；4型成骨不全症，N = 3）进行了为期6个月的全身振动治疗。
通过安装在倾斜台上的振动平台（伽利略系统）进行全身振动。通过测量倾斜角度的变化和评估活动能力（运动功能简要评估）来评估治疗效果。所有个体的特征是通过倾斜角度增加（中位数 = 35度）或地面反作用力增加（开始时中位数 = 30.0 [N/kg]（14.48 - 134.21）；6个月后中位数 = 146.0 [N/kg]（42.46 - 245.25））记录的肌肉力量改善。
全身振动可能是改善严重受成骨不全症影响的儿童和青少年活动能力的一种有前景的方法。
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