天蓝色链霉菌中放线紫红素基因簇的自发扩增，涉及天然插入序列IS466。
Spontaneous amplification of the actinorhodin gene cluster in Streptomyces coelicolor involving native insertion sequence IS466.
作者信息
Widenbrant E M, Tsai Hsiu-Hui, Chen Carton W, Kao C M
机构信息
Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
出版信息
J Bacteriol. 2008 Jul;190(13):4754-8. doi: 10.1128/JB.00131-08. Epub 2008 Apr 25.
Abstract
We observed a spontaneous amplification of the Streptomyces coelicolor chromosome, including genes encoding biosynthetic enzymes of the antibiotic actinorhodin. A new junction of two tandem segments has, inserted within it, a third copy of a transposable element existing in two places elsewhere in the chromosome, suggesting its involvement in the amplification mechanism.
摘要
我们观察到天蓝色链霉菌染色体的自发扩增，包括编码抗生素放线紫红素生物合成酶的基因。两个串联片段的一个新连接处插入了一个转座元件的第三个拷贝，该转座元件在染色体其他位置的两个地方也存在，这表明它参与了扩增机制。
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