Wiener P, Egan S, Huddleston A S, Wellington E M
Department of Biological Sciences, University of Warwick, Coventry, UK.
Mol Ecol. 1998 Sep;7(9):1205-16. doi: 10.1046/j.1365-294x.1998.00450.x.
Phylogenetic analysis was used to evaluate the hypothesis of gene transfer in streptomycetes, many of which are antibiotic producers. The diversity and possible origins of streptomycin-resistance genes was investigated for a population of Streptomyces strains isolated from a site in Brazil where antibiotic production had previously been implicated The analysis provides compelling evidence for the transfer of these genes. Examination of other Streptomyces-type strains also reveals a scattered distribution of streptomycin producers with respect to the overall phylogeny. These results suggest that horizontal gene transfer may be an important factor in the evolution of antibiotic genes in streptomycetes.
系统发育分析被用于评估链霉菌中基因转移的假说，其中许多链霉菌是抗生素产生菌。对从巴西一个曾涉及抗生素生产的地点分离出的一群链霉菌菌株，研究了链霉素抗性基因的多样性和可能起源。该分析为这些基因的转移提供了令人信服的证据。对其他链霉菌类型菌株的研究还揭示，就整体系统发育而言，链霉素产生菌呈分散分布。这些结果表明，水平基因转移可能是链霉菌中抗生素基因进化的一个重要因素。
